Population genomics of Klebsiella pneumoniae

KL Wyres, MMC Lam, KE Holt - Nature Reviews Microbiology, 2020 - nature.com
Klebsiella pneumoniae is a common cause of antimicrobial-resistant opportunistic infections
in hospitalized patients. The species is naturally resistant to penicillins, and members of the …

Klebsiella pneumoniae: going on the offense with a strong defense

MK Paczosa, J Mecsas - Microbiology and molecular biology …, 2016 - Am Soc Microbiol
Klebsiella pneumoniae causes a wide range of infections, including pneumonias, urinary
tract infections, bacteremias, and liver abscesses. Historically, K. pneumoniae has caused …

Salmonella versus the Microbiome

AWL Rogers, RM Tsolis… - … and Molecular Biology …, 2021 - Am Soc Microbiol
SUMMARY A balanced gut microbiota contributes to health, but the mechanisms
maintaining homeostasis remain elusive. Microbiota assembly during infancy is governed by …

[HTML][HTML] Iron in immune cell function and host defense

D Haschka, A Hoffmann, G Weiss - Seminars in Cell & Developmental …, 2021 - Elsevier
The control over iron availability is crucial under homeostatic conditions and even more in
the case of an infection. This results from diverse properties of iron: first, iron is an important …

Transition metals and virulence in bacteria

LD Palmer, EP Skaar - Annual review of genetics, 2016 - annualreviews.org
Transition metals are required trace elements for all forms of life. Due to their unique
inorganic and redox properties, transition metals serve as cofactors for enzymes and other …

Invasive non-typhoidal salmonella disease: an emerging and neglected tropical disease in Africa

NA Feasey, G Dougan, RA Kingsley, RS Heyderman… - The Lancet, 2012 - thelancet.com
Invasive strains of non-typhoidal salmonellae have emerged as a prominent cause of
bloodstream infection in African adults and children, with an associated case fatality of 20 …

Mucosal immunity to pathogenic intestinal bacteria

A Perez-Lopez, J Behnsen, SP Nuccio… - Nature Reviews …, 2016 - nature.com
The intestinal mucosa is a particularly dynamic environment in which the host constantly
interacts with trillions of commensal microorganisms, known as the microbiota, and …

Extraintestinal Pathogenic Escherichia coli: Virulence Factors and Antibiotic Resistance

VM Sora, G Meroni, PA Martino, A Soggiu, L Bonizzi… - Pathogens, 2021 - mdpi.com
The One Health approach emphasizes the importance of antimicrobial resistance (AMR) as
a major concern both in public health and in food animal production systems. As a general …

Pathogenicity Factors of Genomic Islands in Intestinal and Extraintestinal Escherichia coli

M Desvaux, G Dalmasso, R Beyrouthy… - Frontiers in …, 2020 - frontiersin.org
Escherichia coli is a versatile bacterial species that includes both harmless commensal
strains and pathogenic strains found in the gastrointestinal tract in humans and warm …

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

EA Miao, IA Leaf, PM Treuting, DP Mao, M Dors… - Nature …, 2010 - nature.com
Macrophages mediate crucial innate immune responses via caspase-1-dependent
processing and secretion of interleukin 1β (IL-1β) and IL-18. Although infection with wild …