Spatial transcriptomics is revolutionizing modern biology, offering researchers an
unprecedented ability to unravel intricate gene expression patterns within tissues. From …

Alzheimer's disease is a complex, heterogeneous disorder with multiple genetic subtypes.
Spatial and single-cell gene expression analyses of these subtypes have provided new …

Spatial transcriptomics (ST) represents a revolutionary approach in molecular biology,
providing unprecedented insights into the spatial organization of gene expression within …

Paired single-cell and spatially resolved transcriptomics (SRT) data supplement each other,
providing in-depth insights into biological processes and disease mechanisms. Previous …

Alzheimer's disease (AD) is a neurodegenerative disorder marked by cognitive decline,
primarily affecting memory and executive function. This review highlights recent …

Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by the
gradual loss of neurons and the accumulation of amyloid plaques and neurofibrillary …

Rapid advancements in high-throughput single-cell RNA-seq (scRNA-seq) technologies
and experimental protocols have led to the generation of vast amounts of genomic data that …

Advances in spatially-resolved transcriptomics (SRT) technologies have propelled the
development of new computational analysis methods to unlock biological insights. As the …

To enhance understanding of cellular heterogeneity and disease from single-cell
sequencing data, we introduce ResidPCA, a robust method for cell state identification that …

The immune response in the central nervous system (CNS) is a highly specialized and
tightly regulated process essential for maintaining neural health and protecting against …