The origin of ovarian cancer species and precancerous landscape
Unlike other human cancers, in which all primary tumors arise de novo, ovarian epithelial
cancers are primarily imported from either endometrial or fallopian tube epithelium. The …
cancers are primarily imported from either endometrial or fallopian tube epithelium. The …
Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer—shifting the paradigm
Recent morphologic, immunohistochemical, and molecular genetic studies have led to the
development of a new paradigm for the pathogenesis and origin of epithelial ovarian cancer …
development of a new paradigm for the pathogenesis and origin of epithelial ovarian cancer …
Current and emerging methods for ovarian cancer screening and diagnostics: a comprehensive review
Simple Summary Ovarian high-grade serous carcinoma (HGSC) has a 5-year survival rate
of less than 50%, making it one of the most lethal gynecological cancers for women in the …
of less than 50%, making it one of the most lethal gynecological cancers for women in the …
Hippo signaling in the ovary: emerging roles in development, fertility, and disease
Emerging studies indicate that the Hippo pathway, a highly conserved pathway that
regulates organ size control, plays an important role in governing ovarian physiology …
regulates organ size control, plays an important role in governing ovarian physiology …
Epigenetics in ovarian cancer
Y Natanzon, EL Goode, JM Cunningham - Seminars in cancer biology, 2018 - Elsevier
Ovarian cancer is a disease with a poor prognosis and little progress has been made to
improve treatment. It is now recognized that there are several histotypes of ovarian cancer …
improve treatment. It is now recognized that there are several histotypes of ovarian cancer …
KRAS (but not BRAF) mutations in ovarian serous borderline tumour are associated with recurrent low‐grade serous carcinoma
YT Tsang, MT Deavers, CC Sun… - The Journal of …, 2013 - Wiley Online Library
BRAF and KRAS mutations in ovarian serous borderline tumours (OSBTs) and ovarian low‐
grade serous carcinomas (LGSCs) have been previously described. However, whether …
grade serous carcinomas (LGSCs) have been previously described. However, whether …
DNA methylation, histone acetylation and methylation of epigenetic modifications as a therapeutic approach for cancers
Epigenetic modifications play important roles in regulating carcinogenesis, and specific
epigenetic modifications have emerged as potential tumor markers. Herein, we summarize …
epigenetic modifications have emerged as potential tumor markers. Herein, we summarize …
Time to recurrence and survival in serous ovarian tumors predicted from integrated genomic profiles
Background Serous ovarian cancer (SeOvCa) is an aggressive disease with differential and
often inadequate therapeutic outcome after standard treatment. The Cancer Genome Atlas …
often inadequate therapeutic outcome after standard treatment. The Cancer Genome Atlas …
Epigenome-wide ovarian cancer analysis identifies a methylation profile differentiating clear-cell histology with epigenetic silencing of the HERG K+ channel
MS Cicek, DC Koestler, BL Fridley… - Human molecular …, 2013 - academic.oup.com
Ovarian cancer remains the leading cause of death in women with gynecologic
malignancies, despite surgical advances and the development of more effective …
malignancies, despite surgical advances and the development of more effective …
LncRNAs expression profiling in normal ovary, benign ovarian cyst and malignant epithelial ovarian cancer
H Wang, Z Fu, C Dai, J Cao, X Liu, J Xu, M Lv, Y Gu… - Scientific reports, 2016 - nature.com
Long noncoding RNA (lncRNA) has been recognized as a regulator of gene expression,
and the dysregulation of lncRNAs is involved in the progression of many types of cancer …
and the dysregulation of lncRNAs is involved in the progression of many types of cancer …