Conspectus Ynamides are electron-rich heteroatom-substituted alkynes with a C–C triple
bond directly attached to the amide group. Importantly, this amide group is able to impose an …

Natural product synthesis is a highly demanding field in constant need of efficient
transformations that allow either straightforward, scalable, and high-yielding preparation of …

Alkynes represent one of the most important and versatile building blocks in organic
synthesis. Heteroatom-substituted alkynes, which can be considered as subgroups of …

Ynamides display an exceptionally fine balance between stability and reactivity. They also
offer unique and multiple opportunities for the inclusion of nitrogen‐based functionalities into …

The C–N cross-coupling chemistry intensely developed since the late 1990s has supplied
synthesists with an overwhelming number of methods to effectively combine carbon and …

The utility of copper-mediated cross-coupling reactions has been significantly increased by
the development of mild reaction conditions and the ability to employ catalytic amounts of …

In addition to the well-established nucleophilic alkynylation, the use of electrophilic alkynes
can expand tremendously the scope of acetylene transfer reactions. The use of metal …

Conspectus Inspired by the need for green and sustainable chemistry, modern synthetic
chemists have been seeking general and practical ways to construct complex molecules …

A copper-catalyzed method for the preparation of ynamides has been identified that
proceeds via aerobic oxidative coupling of terminal alkynes with various nitrogen …

Enamides display a fine balance of stability and reactivity, which is now leading to their
increasing use in organic synthesis. Enamides offer multiple opportunities for the inclusion …