The occurrence and development of cardiovascular complications are predominantly
responsible for the increased morbidity and mortality observed in patients with diabetes …

Metformin has been extensively used for the treatment of type 2 diabetes, and it may also
promote healthy aging. Despite its widespread use and versatility, metformin's mechanisms …

Ageing can be defined as the progressive failure of repair and maintenance systems with a
consequent accumulation of cellular damage in nucleic acids, proteins, and lipids. These …

Apart from being a safe, effective and globally affordable glucose-lowering agent for the
treatment of diabetes, metformin has earned much credit in recent years as a potential anti …

Proteoglycosylation is the addition of monosaccharides or glycans to the protein peptide
chain. This is a common post-translational modification of proteins with a variety of biological …

Metformin, a biguanide drug, is the most commonly used first-line medication for type 2
diabetes mellites due to its outstanding glucose-lowering ability. After oral administration of …

Aging is a process characterized by accumulating degenerative damages, resulting in the
death of an organism ultimately. The main goal of aging research is to develop therapies …

Metformin, a biguanide, is a widely used antidiabetic drug, which inhibits gluconeogenesis
and is used to treat hyperglycemia in type 2 diabetes. Through activation of AMPK (AMP …

Metformin has been used for treating diabetes mellitus since the late 1950s. In addition to its
antihyperglycemic activity, it was shown to be a potential drug candidate for treating a range …

Previously, we showed that Satureja Khuzestanica Jamzad essential oil (SKEO) and its
major component, carvacrol (CAR), 5-isopropyl-2-methylphenol, has anti-inflammatory, anti …