Osteopontin (OPN) is a multifunctional protein, and although highly expressed in bone, it is
also expressed by various cell types including macrophages, endothelial cells, smooth …

We found for the first time that IL-4 and IL-13, signature type 2 cytokines, are able to induce
periostin expression. We and others have subsequently shown that periostin is highly …

A comprehensive understanding of the changes in gene expression in cell types involved in
idiopathic pulmonary fibrosis (IPF) will shed light on the mechanisms underlying the loss of …

Macrophages are essential for skeletal muscle homeostasis, but how their dysregulation
contributes to the development of fibrosis in muscle disease remains unclear. Here, we used …

The Ashcroft scale for the evaluation of bleomycin-induced lung fibrosis is the analysis of
stained histological samples by visual assessment. Based on the knowledge that this …

Background Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal disorder
characterized by fibroproliferation and excessive accumulation of extracellular matrix in the …

Lizards cannot naturally regenerate limbs but are the closest known relatives of mammals
capable of epimorphic tail regrowth. However, the mechanisms regulating lizard blastema …

Molecular biomarkers are highly desired in idiopathic pulmonary fibrosis (IPF), where they
hold the potential to elucidate underlying disease mechanisms, accelerated drug …

Rationale: Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal interstitial lung disease
(ILD) characterized by abnormal extracellular matrix (ECM) remodeling. We hypothesized …

Perturbation of lung homeostasis is frequently associated with progressive and fatal
respiratory diseases, such as pulmonary fibrosis. Leucine-rich repeat kinase 2 (LRRK2) is …