Looping the genome with SMC complexes
SMC (structural maintenance of chromosomes) protein complexes are an evolutionarily
conserved family of motor proteins that hold sister chromatids together and fold genomes …
conserved family of motor proteins that hold sister chromatids together and fold genomes …
Two major mechanisms of chromosome organization
The spatial organization of chromosomes has long been connected to their polymeric nature
and is believed to be important for their biological functions, including the control of …
and is believed to be important for their biological functions, including the control of …
Real-time imaging of DNA loop extrusion by condensin
It has been hypothesized that SMC protein complexes such as condensin and cohesin
spatially organize chromosomes by extruding DNA into large loops. We directly visualized …
spatially organize chromosomes by extruding DNA into large loops. We directly visualized …
The condensin complex is a mechanochemical motor that translocates along DNA
Condensin plays crucial roles in chromosome organization and compaction, but the
mechanistic basis for its functions remains obscure. We used single-molecule imaging to …
mechanistic basis for its functions remains obscure. We used single-molecule imaging to …
Emerging evidence of chromosome folding by loop extrusion
Chromosome organization poses a remarkable physical problem with many biological
consequences: How can molecular interactions between proteins at the nanometer scale …
consequences: How can molecular interactions between proteins at the nanometer scale …
Human condensin I and II drive extensive ATP-dependent compaction of nucleosome-bound DNA
Structural maintenance of chromosomes (SMC) complexes are essential for genome
organization from bacteria to humans, but their mechanisms of action remain poorly …
organization from bacteria to humans, but their mechanisms of action remain poorly …
Towards a unified model of SMC complex function
M Hassler, IA Shaltiel, CH Haering - Current Biology, 2018 - cell.com
Protein complexes built of structural maintenance of chromosomes (SMC) and kleisin
subunits, including cohesin, condensin and the Smc5/6 complex, are master organizers of …
subunits, including cohesin, condensin and the Smc5/6 complex, are master organizers of …
Structural basis for a safety-belt mechanism that anchors condensin to chromosomes
M Kschonsak, F Merkel, S Bisht, J Metz, V Rybin… - Cell, 2017 - cell.com
Condensin protein complexes coordinate the formation of mitotic chromosomes and thereby
ensure the successful segregation of replicated genomes. Insights into how condensin …
ensure the successful segregation of replicated genomes. Insights into how condensin …
Chromosome organization by one-sided and two-sided loop extrusion
SMC complexes, such as condensin or cohesin, organize chromatin throughout the cell
cycle by a process known as loop extrusion. SMC complexes reel in DNA, extruding and …
cycle by a process known as loop extrusion. SMC complexes reel in DNA, extruding and …
The condensin holocomplex cycles dynamically between open and collapsed states
JK Ryu, AJ Katan, EO van der Sluis, T Wisse… - Nature structural & …, 2020 - nature.com
Structural maintenance of chromosome (SMC) protein complexes are the key organizers of
the spatiotemporal structure of chromosomes. The condensin SMC complex has recently …
the spatiotemporal structure of chromosomes. The condensin SMC complex has recently …