Background The mechanisms underlying the non-antimicrobial immunomodulatory
properties of macrolides are not well understood. Objectives To systematically review the …

The first macrolide, erythromycin A, demonstrated broad-spectrum antimicrobial activity and
was used primarily for respiratory and skin and soft tissue infections. Newer 14-, 15-and 16 …

Susceptibilities to erythromycin by broth microdilution were compared with those to the
newer macrolide clarithromycin for 223 isolates of rapidly growing mycobacteria belonging …

Clarithromycin is an acid-stable orally administered macrolide antimicrobial drug,
structurally related to erythromycin. It has a broad spectrum of antimicrobial activity, similar to …

Erythromycin, the first macrolide antibiotic discovered, has been used since the early 1950s
for the treatment of upper respiratory tract and skin and soft tissue infections caused by …

Macrolide antibiotics possess several, beneficial, secondary properties which complement
their primary antimicrobial activity. In addition to high levels of tissue penetration, which may …

To examine the in vivo effects of macrolide antibiotics on mucus hypersecretion, we induced
hypertrophic and metaplastic changes of goblet cells in rat nasal epithelium by intranasal …

Erythromycin, the first macrolide antibiotic discovered, has been used since the early 1950s
for the treatment of upper respiratory tract and skin and soft tissue infections caused by …

The steady-state concentrations of clarithromycin and azithromycin in plasma were
compared with concomitant concentrations in epithelial lining fluid (ELF) and alveolar …

The newer macrolides and rifamycins (rifabutin) are major advances for treatment or
prophylaxis of disease due to Mycobacterium avium complex. Although rifampin and …