[HTML][HTML] 3D printing of hydrogels: Rational design strategies and emerging biomedical applications

J Li, C Wu, PK Chu, M Gelinsky - Materials Science and Engineering: R …, 2020 - Elsevier
Abstract 3D printing alias additive manufacturing can transform 3D virtual models created by
computer-aided design (CAD) into physical 3D objects in a layer-by-layer manner …

Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Hydrogels with tunable stress relaxation regulate stem cell fate and activity

O Chaudhuri, L Gu, D Klumpers, M Darnell… - Nature materials, 2016 - nature.com
Natural extracellular matrices (ECMs) are viscoelastic and exhibit stress relaxation.
However, hydrogels used as synthetic ECMs for three-dimensional (3D) culture are typically …

High-throughput methods in the discovery and study of biomaterials and materiobiology

L Yang, S Pijuan-Galito, HS Rho, AS Vasilevich… - Chemical …, 2021 - ACS Publications
The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …

Elasticity of nanoparticles influences their blood circulation, phagocytosis, endocytosis, and targeting

AC Anselmo, M Zhang, S Kumar, DR Vogus… - ACS …, 2015 - ACS Publications
The impact of physical and chemical modifications of nanoparticles on their biological
function has been systemically investigated and exploited to improve their circulation and …

Beyond proteases: Basement membrane mechanics and cancer invasion

J Chang, O Chaudhuri - Journal of Cell Biology, 2019 - rupress.org
In epithelial cancers, cells must invade through basement membranes (BMs) to metastasize.
The BM, a thin layer of extracellular matrix underlying epithelial and endothelial tissues, is …

Alginate: properties and biomedical applications

KY Lee, DJ Mooney - Progress in polymer science, 2012 - Elsevier
Alginate is a biomaterial that has found numerous applications in biomedical science and
engineering due to its favorable properties, including biocompatibility and ease of gelation …

Injectable graphene oxide/hydrogel-based angiogenic gene delivery system for vasculogenesis and cardiac repair

A Paul, A Hasan, HA Kindi, AK Gaharwar, VTS Rao… - ACS …, 2014 - ACS Publications
The objective of this study was to develop an injectable and biocompatible hydrogel which
can efficiently deliver a nanocomplex of graphene oxide (GO) and vascular endothelial …

Tissue cells feel and respond to the stiffness of their substrate

DE Discher, P Janmey, Y Wang - Science, 2005 - science.org
Normal tissue cells are generally not viable when suspended in a fluid and are therefore
said to be anchorage dependent. Such cells must adhere to a solid, but a solid can be as …

The effect of sedimentation and diffusion on cellular uptake of gold nanoparticles

EC Cho, Q Zhang, Y Xia - Nature nanotechnology, 2011 - nature.com
In vitro experiments typically measure the uptake of nanoparticles by exposing cells at the
bottom of a culture plate to a suspension of nanoparticles, and it is generally assumed that …