The effect of age, gender, diet and lifestyle on DNA damage measured using micronucleus frequency in human peripheral blood lymphocytes

M Fenech, S Bonassi - Mutagenesis, 2011 - academic.oup.com
Micronucleus (MN) frequency in cytokinesis-blocked peripheral blood lymphocytes (PBL)
has become one of the best-established biomarkers for studying DNA damage occurring in …

The comet assay as a tool for human biomonitoring studies: the ComNet project

A Collins, G Koppen, V Valdiglesias, M Dusinska… - … research/reviews in …, 2014 - Elsevier
The comet assay is widely used in human biomonitoring to measure DNA damage as a
marker of exposure to genotoxic agents or to investigate genoprotective effects. Studies …

Chromothripsis as an on-target consequence of CRISPR–Cas9 genome editing

ML Leibowitz, S Papathanasiou, PA Doerfler… - Nature …, 2021 - nature.com
Genome editing has therapeutic potential for treating genetic diseases and cancer.
However, the currently most practicable approaches rely on the generation of DNA double …

Nanoplastics as a potential environmental health factor: effects of polystyrene nanoparticles on human intestinal epithelial Caco-2 cells

C Cortés, J Domenech, M Salazar, S Pastor… - Environmental …, 2020 - pubs.rsc.org
The ubiquitous and increasing presence of micro-/nanoplastics (MNPLs) in our environment
demands an urgent hazard assessment, in order to determine the potential risk they pose to …

[HTML][HTML] Investigating landfill leachate toxicity in vitro: A review of cell models and endpoints

D Baderna, F Caloni, E Benfenati - Environment international, 2019 - Elsevier
Landfill leachate is a complex mixture characterized by high toxicity and able to contaminate
soils and waters surrounding the dumpsite, especially in developing countries where …

[HTML][HTML] A review of sources, pathways, and toxic effects of human exposure to benzophenone ultraviolet light filters

YN Yao, Y Wang, H Zhang, Y Gao, T Zhang… - Eco-Environment & …, 2024 - Elsevier
Benzophenone ultraviolet light filters (BPs) are high-production-volume chemicals
extensively used in personal care products, leading to widespread human exposure. Given …

Fate of micronuclei and micronucleated cells

H Hintzsche, U Hemmann, A Poth, D Utesch… - … Research/Reviews in …, 2017 - Elsevier
The present review describes available evidence about the fate of micronuclei and
micronucleated cells. Micronuclei are small, extranuclear chromatin bodies surrounded by a …

High arsenic in rice is associated with elevated genotoxic effects in humans

M Banerjee, N Banerjee, P Bhattacharjee, D Mondal… - Scientific reports, 2013 - nature.com
Arsenic in drinking water may cause major deleterious health impacts including death.
Although arsenic in rice has recently been demonstrated to be a potential exposure route for …

Chromothripsis: a new mechanism for rapid karyotype evolution

ML Leibowitz, CZ Zhang, D Pellman - Annual review of genetics, 2015 - annualreviews.org
Chromosomal rearrangements are generally thought to accumulate gradually over many
generations. However, DNA sequencing of cancer and congenital disorders uncovered a …

The molecular origins and pathophysiological consequences of micronuclei: New insights into an age-old problem

X Guo, J Ni, Z Liang, J Xue, MF Fenech… - … Research/Reviews in …, 2019 - Elsevier
Micronuclei (MN), the small nucleus-like bodies separated from the primary nucleus, can
exist in cells with numerical and/or structural chromosomal aberrations in apparently normal …