Genome-wide association studies (GWAS) test hundreds of thousands of genetic variants
across many genomes to find those statistically associated with a specific trait or disease …

Inflammatory bowel disease (IBD), as a global disease, has attracted much research
interest. Constant research has led to a better understanding of the disease condition and …

Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease whose incidence has
risen worldwide in recent years. Accumulating evidence shows that oxidative stress plays an …

Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signal
transduction mediates cytokine responses. Canonical signaling is based on STAT tyrosine …

Background In patients with Crohn's disease, the efficacy of ustekinumab, a human
monoclonal antibody against interleukin-12 and interleukin-23, is unknown. Methods We …

Prostaglandins (PGs) are the major lipid mediators in animals and which are biosynthesized
from arachidonic acid by the cyclooxygenases (COX-1 or COX-2) as the rate-limiting …

Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …

Genome-wide association studies (GWAS) of psychiatric disorders have identified multiple
genetic associations with such disorders, but better methods are needed to derive the …

By combining genome-wide association data from 8,130 individuals with type 2 diabetes
(T2D) and 38,987 controls of European descent and following up previously unidentified …

Genome-wide association (GWA) studies have typically focused on the analysis of single
markers, which often lacks the power to uncover the relatively small effect sizes conferred by …