RNA m6A methylation across the transcriptome
E Sendinc, Y Shi - Molecular cell, 2023 - cell.com
Since the early days of foundational studies of nucleic acids, many chemical moieties have
been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one …
been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one …
The roles and implications of RNA m6A modification in cancer
Abstract N 6-Methyladenosine (m6A), the most prevalent internal modification in eukaryotic
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
[HTML][HTML] RNA modifications: importance in immune cell biology and related diseases
L Cui, R Ma, J Cai, C Guo, Z Chen, L Yao… - Signal transduction and …, 2022 - nature.com
RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …
including generation, transportation, function, and metabolization, they act as critical …
[HTML][HTML] The proteins of mRNA modification: writers, readers, and erasers
MN Flamand, M Tegowski… - Annual review of …, 2023 - annualreviews.org
Over the past decade, mRNA modifications have emerged as important regulators of gene
expression control in cells. Fueled in large part by the development of tools for detecting …
expression control in cells. Fueled in large part by the development of tools for detecting …
The molecular basis of translation initiation and its regulation in eukaryotes
J Brito Querido, I Díaz-López… - Nature Reviews Molecular …, 2024 - nature.com
The regulation of gene expression is fundamental for life. Whereas the role of transcriptional
regulation of gene expression has been studied for several decades, it has been clear over …
regulation of gene expression has been studied for several decades, it has been clear over …
METTL3 preferentially enhances non-m6A translation of epigenetic factors and promotes tumourigenesis
X Wei, Y Huo, J Pi, Y Gao, S Rao, M He, Q Wei… - Nature cell …, 2022 - nature.com
METTL3 encodes the predominant catalytic enzyme to promote m6A methylation in nucleus.
Recently, accumulating evidence has shown the expression of METTL3 in cytoplasm, but its …
Recently, accumulating evidence has shown the expression of METTL3 in cytoplasm, but its …
[HTML][HTML] Lactylation of METTL16 promotes cuproptosis via m6A-modification on FDX1 mRNA in gastric cancer
L Sun, Y Zhang, B Yang, S Sun, P Zhang, Z Luo… - Nature …, 2023 - nature.com
Cuproptosis, caused by excessively high copper concentrations, is urgently exploited as a
potential cancer therapeutic. However, the mechanisms underlying the initiation …
potential cancer therapeutic. However, the mechanisms underlying the initiation …
METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism
Summary N 6-methyladenosine (m 6 A), the most prevalent internal modification in
mammalian mRNAs, is involved in many pathological processes. METTL16 is a recently …
mammalian mRNAs, is involved in many pathological processes. METTL16 is a recently …
QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism
Summary N 7-methylguanosine (m 7 G) modification, routinely occurring at mRNA 5′ cap
or within tRNAs/rRNAs, also exists internally in messenger RNAs (mRNAs). Although m 7 G …
or within tRNAs/rRNAs, also exists internally in messenger RNAs (mRNAs). Although m 7 G …
[HTML][HTML] METTL16 promotes hepatocellular carcinoma progression through downregulating RAB11B-AS1 in an m6A-dependent manner
Y Dai, Y Liu, J Li, M Chen, M Huang, F Wang… - Cellular & molecular …, 2022 - Springer
Background The molecular mechanisms driving hepatocellular carcinoma (HCC) remain
largely unclear. As one of the major epitranscriptomic modifications, N 6-methyladenosine …
largely unclear. As one of the major epitranscriptomic modifications, N 6-methyladenosine …