WNT signaling in cardiac and vascular disease
S Foulquier, EP Daskalopoulos, G Lluri… - Pharmacological …, 2018 - ASPET
WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …
mediated by multiple signaling molecules. WNT signaling is critically important for …
Secreted and transmembrane wnt inhibitors and activators
CM Cruciat, C Niehrs - Cold Spring Harbor perspectives …, 2013 - cshperspectives.cshlp.org
Signaling by the Wnt family of secreted glycoproteins plays important roles in embryonic
development and adult homeostasis. Wnt signaling is modulated by a number of …
development and adult homeostasis. Wnt signaling is modulated by a number of …
[HTML][HTML] The mouse retina as an angiogenesis model
The mouse retina has been used extensively over the past decades to study both
physiologic and pathologic angiogenesis. Over time, various mouse retina models have …
physiologic and pathologic angiogenesis. Over time, various mouse retina models have …
TSPAN12 regulates retinal vascular development by promoting Norrin-but not Wnt-induced FZD4/β-catenin signaling
HJ Junge, S Yang, JB Burton, K Paes, X Shu… - Cell, 2009 - cell.com
Mutations in the genes encoding the Wnt receptor Frizzled-4 (FZD4), coreceptor LRP5, or
the ligand Norrin disrupt retinal vascular development and cause ophthalmic diseases …
the ligand Norrin disrupt retinal vascular development and cause ophthalmic diseases …
Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy
H Park, H Yamamoto, L Mohn, L Ambühl… - Nature …, 2019 - nature.com
Familial exudative vitreoretinopathy (FEVR) is a human disease characterized by defective
retinal angiogenesis and associated complications that can result in vision loss. Defective …
retinal angiogenesis and associated complications that can result in vision loss. Defective …
Molecular parallels between neural and vascular development
A Eichmann, JL Thomas - Cold Spring …, 2013 - perspectivesinmedicine.cshlp.org
The human central nervous system (CNS) features a network of∼ 400 miles of blood
vessels that receives> 20% of the body's cardiac output and uses most of its blood glucose …
vessels that receives> 20% of the body's cardiac output and uses most of its blood glucose …
A comprehensive overview of skeletal phenotypes associated with alterations in Wnt/β-catenin signaling in humans and mice
KA Maupin, CJ Droscha, BO Williams - Bone Research, 2013 - nature.com
The Wnt signaling pathway plays key roles in differentiation and development and
alterations in this signaling pathway are causally associated with numerous human …
alterations in this signaling pathway are causally associated with numerous human …
A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy
Abstract The FZD4: LRP5: TSPAN12 receptor complex is activated by the secreted protein
Norrin in retinal endothelial cells and leads to βcatenin‐dependent formation of the blood …
Norrin in retinal endothelial cells and leads to βcatenin‐dependent formation of the blood …
Comparison of bevacizumab, ranibizumab, and laser photocoagulation in the treatment of retinopathy of prematurity in Turkey
Purpose: To evaluate the efficacies and treatment outcomes following intravitreal
bevacizumab (IVB), intravitreal ranibizumab (IVR), and laser photocoagulation (LPC) in …
bevacizumab (IVB), intravitreal ranibizumab (IVR), and laser photocoagulation (LPC) in …
Vascular morphogenesis: a Wnt for every vessel?
Blood vessel development requires orchestrated activities of heterogeneous endothelial cell
(EC) populations to create a hierarchically branched tubular network. Endothelial …
(EC) populations to create a hierarchically branched tubular network. Endothelial …