TRPC6 channels and their binding partners in podocytes: role in glomerular filtration and pathophysiology
Loss or dysfunction of podocytes is a major cause of glomerular kidney disease. Several
genetic forms of glomerular disease are caused by mutations in genes that encode structural …
genetic forms of glomerular disease are caused by mutations in genes that encode structural …
The role of calcium signaling in melanoma
H Zhang, Z Chen, A Zhang, AA Gupte… - International journal of …, 2022 - mdpi.com
Calcium signaling plays important roles in physiological and pathological conditions,
including cutaneous melanoma, the most lethal type of skin cancer. Intracellular calcium …
including cutaneous melanoma, the most lethal type of skin cancer. Intracellular calcium …
[HTML][HTML] Absence of filamin A prevents cells from responding to stiffness gradients on gels coated with collagen but not fibronectin
Cell types from many tissues respond to changes in substrate stiffness by actively
remodeling their cytoskeletons to alter spread area or adhesion strength, and in some cases …
remodeling their cytoskeletons to alter spread area or adhesion strength, and in some cases …
Small-conductance calcium-activated potassium channels in the heart: expression, regulation and pathological implications
T Liu, T Li, D Xu, Y Wang, Y Zhou… - … of the Royal …, 2023 - royalsocietypublishing.org
Ca2+-activated K+ channels are critical to cellular Ca2+ homeostasis and excitability; they
couple intracellular Ca2+ and membrane voltage change. Of these, the small, 4–14 pS …
couple intracellular Ca2+ and membrane voltage change. Of these, the small, 4–14 pS …
Calmodulin and CaMKII modulate ENaC activity by regulating the association of MARCKS and the cytoskeleton with the apical membrane
Phosphatidylinositol bisphosphate (PIP2) regulates epithelial sodium channel (ENaC) open
probability. In turn, myristoylated alanine-rich C kinase substrate (MARCKS) protein or …
probability. In turn, myristoylated alanine-rich C kinase substrate (MARCKS) protein or …
Functional interaction with filamin A and intracellular Ca2+ enhance the surface membrane expression of a small-conductance Ca2+-activated K+ (SK2) channel
S Rafizadeh, Z Zhang, RL Woltz… - Proceedings of the …, 2014 - National Acad Sciences
For an excitable cell to function properly, a precise number of ion channel proteins need to
be trafficked to distinct locations on the cell surface membrane, through a network and …
be trafficked to distinct locations on the cell surface membrane, through a network and …
Disease-associated substitutions in the filamin B actin binding domain confer enhanced actin binding affinity in the absence of major structural disturbance: Insights …
GM Sawyer, AR Clark, SP Robertson… - Journal of molecular …, 2009 - Elsevier
Missense mutations in filamin B (FLNB) are associated with the autosomal dominant
atelosteogenesis (AO) and the Larsen group of skeletal malformation disorders. These …
atelosteogenesis (AO) and the Larsen group of skeletal malformation disorders. These …
Filamin A protein interacts with human immunodeficiency virus type 1 Gag protein and contributes to productive particle assembly
JA Cooper, L Liu, EA Woodruff, HE Taylor… - Journal of Biological …, 2011 - ASBMB
HIV-1 Gag precursor directs virus particle assembly and release. In a search for Gag-
interacting proteins that are involved in late stages of the HIV-1 replication cycle, we …
interacting proteins that are involved in late stages of the HIV-1 replication cycle, we …
AF17 competes with AF9 for binding to Dot1a to up-regulate transcription of epithelial Na+ channel α
MR Reisenauer, M Anderson, L Huang, Z Zhang… - Journal of Biological …, 2009 - ASBMB
We previously reported that Dot1a· AF9 complex represses transcription of the epithelial
Na+ channel subunit α (α-ENaC) gene in mouse inner medullary collecting duct mIMCD3 …
Na+ channel subunit α (α-ENaC) gene in mouse inner medullary collecting duct mIMCD3 …
Nephrin binds to the COOH terminus of a large-conductance Ca2+-activated K+ channel isoform and regulates its expression on the cell surface
We carried out a yeast two-hybrid screen to identify proteins that interact with large-
conductance Ca2+-activated K+ (BKCa) channels encoded by the Slo1 gene. Nephrin, an …
conductance Ca2+-activated K+ (BKCa) channels encoded by the Slo1 gene. Nephrin, an …