Several new discoveries have revived interest in the pathogenic potential and possible
clinical roles of IL-18. IL-18 is an IL-1 family cytokine with potent ability to induce IFNγ …

Systemic juvenile idiopathic arthritis (sJIA) is an inflammatory disease with hallmarks of
severe systemic inflammation, which can be accompanied by arthritis. Contemporary …

Still's disease is a rare inflammatory syndrome that encompasses systemic juvenile
idiopathic arthritis and adult-onset Still's disease, both of which can exhibit life-threatening …

Objective Systemic juvenile idiopathic arthritis–associated lung disease (SJIA‐LD) is a life‐
threatening disease complication. Key questions remain regarding clinical course and …

Juvenile idiopathic arthritis (JIA) is a heterogeneous group of diseases with probably
differential underlying physiopathology. Despite the revolutionary era of biologics, some …

Systemic juvenile idiopathic arthritis (sJIA, Still disease) is a rare childhood arthropathy that
is thought to represent a continuous disease spectrum with adult-onset Still disease …

Macrophage activation syndrome (MAS) is a life-threatening complication of pediatric
rheumatic diseases, occurring most commonly in children with systemic juvenile idiopathic …

Chronic lung disease in children with systemic juvenile idiopathic arthritis (SJIA-LD) is an
emerging and potentially life-threatening disease complication. Despite recent descriptions …

Introduction: Biological disease-modifying anti-rheumatic drugs (bDMARDs) targeting
interleukin (IL)-6 and IL-1β represent a steroid-sparing first-line therapy used in systemic …

Interleukin-18 (IL-18) is a potent pro-inflammatory cytokine that is involved in various innate
and adaptive immune processes related to infection, inflammation, and autoimmunity …