Poly (ADP-ribose) polymerase is a chromatin-bound enzyme which, on activation by DNA
strand breaks, catalyzes the successive transfer of ADP-ribose units from NAD to nuclear …

The ends of human chromosomes are protected by DNA–protein complexes termed
telomeres, which prevent the chromosomes from fusing with each other and from being …

To determine the biochemical basis of the oxidant-induced injury of cells, we have studied
early changes after exposure of P388D1 murine macrophages to hydrogen peroxide. Total …

Poly (ADP-ribose) synthetase of Mr= 120,000 is cleaved by limited proteolysis with alpha-
chymotrypsin into two fragments of Mr= 54,000 (54K) and Mr= 66,000 (66K). When the …

Deoxyadenosine has been implicated as the toxic metabolite causing profound
lymphopenia in immunodeficient children with a genetic deficiency of adenosine deaminase …

Of the many known covalent modifications of proteins1, few have been recognized as
widespread. Among these modifications, protein phosphorylation has been extensively …

ADP-ribosylation of Histone H1( Abstract_要旨 ) Page 1 RIGHT: URL: CITATION: AUTHOR(S):
ISSUE DATE: TITLE: ADP-ribosylation of Histone H1( Abstract_要旨 ) Ogata, Norio Ogata …

Acetylaminofluorene and 2-aminofluorene are among the most intensively studied of all
chemical mutagens and carcinogens. Fundamental research findings concerning the …

An intimate relationship exists between DNA single-strand breaks, NAD metabolism, and
cell viability in quiescent human lymphocytes. Under steady-state conditions, resting …

Apoptosis (programmed cell death) is a central protective response to excess oxidative
damage (especially DNA damage), and is also essential to embryogenesis. morphogenesis …