Green chemistry in the synthesis of pharmaceuticals

S Kar, H Sanderson, K Roy, E Benfenati… - Chemical …, 2021 - ACS Publications
The principles of green chemistry (GC) can be comprehensively implemented in green
synthesis of pharmaceuticals by choosing no solvents or green solvents (preferably water) …

Recent advances in the iron‐catalysed multicomponent reactions

S Saranya, T Aneeja, M Neetha… - Applied Organometallic …, 2020 - Wiley Online Library
Iron‐catalysed reactions are widely used in organic synthesis owing to its benefits over other
metals. Among the important organic reactions, multicomponent reactions play a significant …

Asymmetric deoxygenative alkynylation of tertiary amides enabled by iridium/copper bimetallic relay catalysis

Z Li, F Zhao, W Ou, PQ Huang, X Wang - Angewandte Chemie, 2021 - Wiley Online Library
A variety of inert tertiary amides have been successfully transformed into synthetically
important chiral propargylamines in high yields with good to excellent enantioselectivities …

Enantioselective reductive cyanation and phosphonylation of secondary amides by iridium and chiral thiourea sequential catalysis

DH Chen, WT Sun, CJ Zhu, GS Lu… - Angewandte Chemie …, 2021 - Wiley Online Library
The combination of transition‐metal catalysis and organocatalysis increasingly offers
chemists opportunities to realize diverse unprecedented chemical transformations. By …

Selective reduction of secondary amides to imines catalysed by Schwartz's reagent

LJ Donnelly, JC Berthet, T Cantat - Angewandte Chemie, 2022 - Wiley Online Library
The partial reduction of amides is a challenging transformation that must overcome the
intrinsic stability of the amide bond and exhibit high chemoselective control to avoid …

Mild divergent semireductive transformations of secondary and tertiary amides via zirconocene hydride catalysis

RA Kehner, G Zhang… - Journal of the American …, 2023 - ACS Publications
The mild catalytic partial reduction of amides to imines has proven to be a challenging
synthetic transformation, with many transition metals directly reducing these substrates to …

Reverse polarity reductive functionalization of tertiary amides via a dual iridium-catalyzed hydrosilylation and single electron transfer strategy

T Rogova, P Gabriel, S Zavitsanou, JA Leitch… - ACS …, 2020 - ACS Publications
A strategy for the mild generation of synthetically valuable α-amino radicals from robust
tertiary amide building blocks has been developed. By combining Vaska's complex …

Uniting Amide Synthesis and Activation by PIII/PV–Catalyzed Serial Condensation: Three-Component Assembly of 2-Amidopyridines

JM Lipshultz, AT Radosevich - Journal of the American Chemical …, 2021 - ACS Publications
An organophosphorus (PIII/PV redox) catalyzed method for the three-component
condensation of amines, carboxylic acids, and pyridine N-oxides to generate 2 …

Homoleptic bis (trimethylsilyl) amides of yttrium complexes catalyzed hydroboration reduction of amides to amines

P Ye, Y Shao, X Ye, F Zhang, R Li, J Sun, B Xu… - Organic …, 2020 - ACS Publications
Homoleptic lanthanide complex Y [N (TMS) 2] 3 is an efficient homogeneous catalyst for the
hydroboration reduction of secondary amides and tertiary amides to corresponding amines …

Concise Total Synthesis of (−)‐Quinocarcin Enabled by Catalytic Enantioselective Reductive 1, 3‐Dipolar Cycloaddition of Secondary Amides

KL Ji, SF He, DD Xu, WX He, JF Zheng… - Angewandte Chemie …, 2023 - Wiley Online Library
A concise asymmetric total synthesis of (−)‐quinocarcin has been accomplished with high
step economy from commercially available starting materials. A catalytic enantioselective …