Looking at the disordered proteins through the computational microscope
Intrinsically disordered proteins (IDPs) have attracted wide interest over the past decade due
to their surprising prevalence in the proteome and versatile roles in cell physiology and …
to their surprising prevalence in the proteome and versatile roles in cell physiology and …
Conformational studies of pathogenic expanded polyglutamine protein deposits from Huntington's disease
I Matlahov, PCA van der Wel - Experimental biology and …, 2019 - journals.sagepub.com
Huntington's disease, like other neurodegenerative diseases, continues to lack an effective
cure. Current treatments that address early symptoms ultimately fail Huntington's disease …
cure. Current treatments that address early symptoms ultimately fail Huntington's disease …
Monomeric huntingtin exon 1 has similar overall structural features for wild-type and pathological polyglutamine lengths
Huntington's disease is caused by expansion of a polyglutamine (polyQ) domain within exon
1 of the huntingtin gene (Httex1). The prevailing hypothesis is that the monomeric Httex1 …
1 of the huntingtin gene (Httex1). The prevailing hypothesis is that the monomeric Httex1 …
Structural basis of huntingtin fibril polymorphism revealed by cryogenic electron microscopy of exon 1 HTT fibrils
The lack of detailed insight into the structure of aggregates formed by the huntingtin protein
(HTT) has hampered the efforts to develop therapeutics and diagnostics targeting pathology …
(HTT) has hampered the efforts to develop therapeutics and diagnostics targeting pathology …
Aggregation landscapes of Huntingtin exon 1 protein fragments and the critical repeat length for the onset of Huntington's disease
M Chen, PG Wolynes - … of the National Academy of Sciences, 2017 - National Acad Sciences
Huntington's disease (HD) is a neurodegenerative disease caused by an abnormal
expansion in the polyglutamine (polyQ) track of the Huntingtin (HTT) protein. The severity of …
expansion in the polyglutamine (polyQ) track of the Huntingtin (HTT) protein. The severity of …
OpenAWSEM with Open3SPN2: A fast, flexible, and accessible framework for large-scale coarse-grained biomolecular simulations
We present OpenAWSEM and Open3SPN2, new cross-compatible implementations of
coarse-grained models for protein (AWSEM) and DNA (3SPN2) molecular dynamics …
coarse-grained models for protein (AWSEM) and DNA (3SPN2) molecular dynamics …
A free energy barrier caused by the refolding of an oligomeric intermediate controls the lag time of amyloid formation by hIAPP
AL Serrano, JP Lomont, LH Tu… - Journal of the …, 2017 - ACS Publications
Transiently populated oligomers formed en route to amyloid fibrils may constitute the most
toxic aggregates associated with many amyloid-associated diseases. Most nucleation …
toxic aggregates associated with many amyloid-associated diseases. Most nucleation …
[HTML][HTML] Tadpole-like conformations of huntingtin exon 1 are characterized by conformational heterogeneity that persists regardless of polyglutamine length
Abstract Soluble huntingtin exon 1 (Httex1) with expanded polyglutamine (polyQ) engenders
neurotoxicity in Huntington's disease. To uncover the physical basis of this toxicity, we …
neurotoxicity in Huntington's disease. To uncover the physical basis of this toxicity, we …
Exploring the interplay between fibrillization and amorphous aggregation channels on the energy landscapes of tau repeat isoforms
Filaments made up of different isoforms of tau protein are associated with a variety of
neurodegenerative diseases. Filaments made up of the 4R-tau isoform, which has four …
neurodegenerative diseases. Filaments made up of the 4R-tau isoform, which has four …
Distinct oligomerization and fibrillization dynamics of amyloid core sequences of amyloid-beta and islet amyloid polypeptide
A direct observation of amyloid aggregation from isolated peptides to cross-β fibrils is crucial
for understanding the nucleation-dependence process, but the corresponding macroscopic …
for understanding the nucleation-dependence process, but the corresponding macroscopic …