Groucho proteins are abundant and broadly expressed nuclear factors that lack intrinsic
DNA-binding activity but can interact with a variety of DNA-binding proteins. The recruitment …

Abstract Drosophila Groucho (Gro) is the founding member of a family of metazoan
corepressors. Gro mediates repression through interactions with a myriad of DNA-binding …

Somitogenesis is thought to be controlled by a segmentation clock, which consists of
molecular oscillators in the Wnt3a, Fgf8 and Notch pathways. Using conditional alleles of …

The design of effective cell replacement therapies requires detailed knowledge of how
embryonic stem cells form primary tissues, such as mesoderm or neurectoderm that later …

Retinoic acid signaling is a major component of the neural posteriorizing process in
vertebrate development. Here, we identify a new role for the retinoic acid receptor (RAR) in …

The pharyngeal apparatus is a transient structure that gives rise to the thymus and the
parathyroid glands and also contributes to the development of arteries and the cardiac …

The precise border of somites formed during mouse somitogenesis is defined by a Tbx6
expression domain, which is established by Mesp2-mediated Tbx6 suppression in the …

Somitogenesis in vertebrates is a complex and dynamic process involving many sequences
of events generated from the segmentation clock. Previous studies with mouse embryos …

Activation of Map kinase/Erk signalling downstream of fibroblast growth factor (Fgf) tyrosine
kinase receptors regulates gene expression required for mesoderm induction and patterning …

The regions of expression of Ripply1 and Ripply2, presumptive transcriptional corepressors,
overlap at the presomitic mesoderm during somitogenesis in mouse and zebrafish. Ripply1 …