Glioma targeted therapy: insight into future of molecular approaches
Gliomas are the common type of brain tumors originating from glial cells. Epidemiologically,
gliomas occur among all ages, more often seen in adults, which males are more susceptible …
gliomas occur among all ages, more often seen in adults, which males are more susceptible …
Molecular targeted therapy of glioblastoma
E Le Rhun, M Preusser, P Roth, DA Reardon… - Cancer treatment …, 2019 - Elsevier
Glioblastomas are intrinsic brain tumors thought to originate from neuroglial stem or
progenitor cells. More than 90% of glioblastomas are isocitrate dehydrogenase (IDH) …
progenitor cells. More than 90% of glioblastomas are isocitrate dehydrogenase (IDH) …
Glioblastoma multiforme: Pathogenesis and treatment
C Alifieris, DT Trafalis - Pharmacology & therapeutics, 2015 - Elsevier
Abstract Each year, about 5–6 cases out of 100,000 people are diagnosed with primary
malignant brain tumors, of which about 80% are malignant gliomas (MGs). Glioblastoma …
malignant brain tumors, of which about 80% are malignant gliomas (MGs). Glioblastoma …
Diverse signaling mechanisms of mTOR complexes: mTORC1 and mTORC2 in forming a formidable relationship
M Jhanwar-Uniyal, JV Wainwright, AL Mohan… - Advances in biological …, 2019 - Elsevier
Activation of Mechanistic target of rapamycin (mTOR) signaling plays a crucial role in
tumorigenesis of numerous malignancies including glioblastoma (GB). The Canonical …
tumorigenesis of numerous malignancies including glioblastoma (GB). The Canonical …
Targeting cellular pathways in glioblastoma multiforme
JRD Pearson, T Regad - Signal transduction and targeted therapy, 2017 - nature.com
Glioblastoma multiforme (GBM) is a debilitating disease that is associated with poor
prognosis, short median patient survival and a very limited response to therapies. GBM has …
prognosis, short median patient survival and a very limited response to therapies. GBM has …
[HTML][HTML] PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma
X Li, C Wu, N Chen, H Gu, A Yen, L Cao, E Wang… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Glioblastoma multiform (GBM) is the most common malignant glioma of all the brain tumors
and currently effective treatment options are still lacking. GBM is frequently accompanied …
and currently effective treatment options are still lacking. GBM is frequently accompanied …
Exciting new advances in neuro‐oncology: the avenue to a cure for malignant glioma
EG Van Meir, CG Hadjipanayis… - CA: a cancer journal …, 2010 - Wiley Online Library
Malignant gliomas are the most common and deadly brain tumors. Nevertheless, survival for
patients with glioblastoma, the most aggressive glioma, although individually variable, has …
patients with glioblastoma, the most aggressive glioma, although individually variable, has …
Malignant gliomas in adults
Malignant gliomas, the most common type of primary brain tumor in adults, are associated
with disproportionate cancer-related morbidity and mortality. Recently, there have been …
with disproportionate cancer-related morbidity and mortality. Recently, there have been …
Malignant astrocytic glioma: genetics, biology, and paths to treatment
FB Furnari, T Fenton, RM Bachoo… - Genes & …, 2007 - genesdev.cshlp.org
Malignant astrocytic gliomas such as glioblastoma are the most common and lethal
intracranial tumors. These cancers exhibit a relentless malignant progression characterized …
intracranial tumors. These cancers exhibit a relentless malignant progression characterized …
A systematic review of glioblastoma-targeted therapies in phases II, III, IV clinical trials
E Cruz Da Silva, MC Mercier, N Etienne-Selloum… - Cancers, 2021 - mdpi.com
Simple Summary This review describes in a very detailed and exhaustive approach the
literature of these last 20 years on glioblastoma targeted therapies in Phases II-IV of 257 …
literature of these last 20 years on glioblastoma targeted therapies in Phases II-IV of 257 …