Glioma targeted therapy: insight into future of molecular approaches

K Yang, Z Wu, H Zhang, N Zhang, W Wu, Z Wang… - Molecular Cancer, 2022 - Springer
Gliomas are the common type of brain tumors originating from glial cells. Epidemiologically,
gliomas occur among all ages, more often seen in adults, which males are more susceptible …

Molecular targeted therapy of glioblastoma

E Le Rhun, M Preusser, P Roth, DA Reardon… - Cancer treatment …, 2019 - Elsevier
Glioblastomas are intrinsic brain tumors thought to originate from neuroglial stem or
progenitor cells. More than 90% of glioblastomas are isocitrate dehydrogenase (IDH) …

Glioblastoma multiforme: Pathogenesis and treatment

C Alifieris, DT Trafalis - Pharmacology & therapeutics, 2015 - Elsevier
Abstract Each year, about 5–6 cases out of 100,000 people are diagnosed with primary
malignant brain tumors, of which about 80% are malignant gliomas (MGs). Glioblastoma …

Diverse signaling mechanisms of mTOR complexes: mTORC1 and mTORC2 in forming a formidable relationship

M Jhanwar-Uniyal, JV Wainwright, AL Mohan… - Advances in biological …, 2019 - Elsevier
Activation of Mechanistic target of rapamycin (mTOR) signaling plays a crucial role in
tumorigenesis of numerous malignancies including glioblastoma (GB). The Canonical …

Targeting cellular pathways in glioblastoma multiforme

JRD Pearson, T Regad - Signal transduction and targeted therapy, 2017 - nature.com
Glioblastoma multiforme (GBM) is a debilitating disease that is associated with poor
prognosis, short median patient survival and a very limited response to therapies. GBM has …

[HTML][HTML] PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma

X Li, C Wu, N Chen, H Gu, A Yen, L Cao, E Wang… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Glioblastoma multiform (GBM) is the most common malignant glioma of all the brain tumors
and currently effective treatment options are still lacking. GBM is frequently accompanied …

Exciting new advances in neuro‐oncology: the avenue to a cure for malignant glioma

EG Van Meir, CG Hadjipanayis… - CA: a cancer journal …, 2010 - Wiley Online Library
Malignant gliomas are the most common and deadly brain tumors. Nevertheless, survival for
patients with glioblastoma, the most aggressive glioma, although individually variable, has …

Malignant gliomas in adults

PY Wen, S Kesari - New England Journal of Medicine, 2008 - Mass Medical Soc
Malignant gliomas, the most common type of primary brain tumor in adults, are associated
with disproportionate cancer-related morbidity and mortality. Recently, there have been …

Malignant astrocytic glioma: genetics, biology, and paths to treatment

FB Furnari, T Fenton, RM Bachoo… - Genes & …, 2007 - genesdev.cshlp.org
Malignant astrocytic gliomas such as glioblastoma are the most common and lethal
intracranial tumors. These cancers exhibit a relentless malignant progression characterized …

A systematic review of glioblastoma-targeted therapies in phases II, III, IV clinical trials

E Cruz Da Silva, MC Mercier, N Etienne-Selloum… - Cancers, 2021 - mdpi.com
Simple Summary This review describes in a very detailed and exhaustive approach the
literature of these last 20 years on glioblastoma targeted therapies in Phases II-IV of 257 …