Abstract The Nrf2/Keap1 pathway is an important signaling cascade responsible for the
resistance of oxidative damage induced by exogenous chemicals. It maintains the redox …

Multipotent mesenchymal stem cells (MSCs) have been considerably inspected as effective
tool for cell-based therapy of inflammatory, immune-mediated, and degenerative diseases …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is ubiquitously expressed in most eukaryotic
cells and functions to induce a broad range of cellular defenses against exogenous and …

Mesenchymal stromal cells (MSCs) are currently widely used in cell based therapy
regarding to their remarkable efficacy in controlling the inflammatory status in patients …

Mesenchymal stem cells form a population of self‐renewing, multipotent cells that can be
isolated from several tissues. Multiple preclinical studies have demonstrated that the …

Several experimental studies have provided evidence that bone-marrow derived
mesenchymal stem (stromal) cells (MSC) may be effective in treating critically ill surgical …

Bone metabolism is closely related to oxidative stress. As one of the core regulatory factors
of oxidative stress, NRF2 itself and its regulation of oxidative stress are both involved in …

Abstract Lipocalin-2 (LCN2) is an acute phase protein with multiple functions that has
garnered a great deal of interest over the last decade. However, its precise role in the …

Critically ill patients often suffer from multiple organ failures involving lung, kidney, liver or
brain. Genomic, proteomic and metabolomic approaches highlight common injury …

Stem cell aging is a process in which stem cells progressively lose their ability to self-renew
or differentiate, succumb to senescence or apoptosis, and eventually become functionally …