Modeling influenza virus infection: a roadmap for influenza research

A Boianelli, VK Nguyen, T Ebensen, K Schulze, E Wilk… - Viruses, 2015 - mdpi.com
Influenza A virus (IAV) infection represents a global threat causing seasonal outbreaks and
pandemics. Additionally, secondary bacterial infections, caused mainly by Streptococcus …

Host‐pathogen kinetics during influenza infection and coinfection: insights from predictive modeling

AM Smith - Immunological reviews, 2018 - Wiley Online Library
Influenza virus infections are a leading cause of morbidity and mortality worldwide. This is
due in part to the continual emergence of new viral variants and to synergistic interactions …

[HTML][HTML] In-host modeling

SM Ciupe, JM Heffernan - Infectious Disease Modelling, 2017 - Elsevier
Understanding the mechanisms governing host-pathogen kinetics is important and can
guide human interventions. In-host mathematical models, together with biological data, have …

Dynamically linking influenza virus infection kinetics, lung injury, inflammation, and disease severity

MA Myers, AP Smith, LC Lane, DJ Moquin, R Aogo… - Elife, 2021 - elifesciences.org
Influenza viruses cause a significant amount of morbidity and mortality. Understanding host
immune control efficacy and how different factors influence lung injury and disease severity …

Dynamical modelling of viral infection and cooperative immune protection in COVID-19 patients

Z Zhou, D Li, Z Zhao, S Shi, J Wu, J Li… - PLOS Computational …, 2023 - journals.plos.org
Once challenged by the SARS-CoV-2 virus, the human host immune system triggers a
dynamic process against infection. We constructed a mathematical model to describe host …

Review of mathematical modeling of the inflammatory response in lung infections and injuries

SB Minucci, RL Heise, AM Reynolds - Frontiers in Applied …, 2020 - frontiersin.org
Lung inflammation may occur due to viral and bacterial infections, structural damage, or
inhalation of dangerous particles. These injuries may be quickly resolved by the immune …

Protective effects of phillyrin against influenza A virus in vivo

X Qu, Q Li, H Zhang, X Zhang, P Shi, X Zhang… - Archives of pharmacal …, 2016 - Springer
Influenza A virus infection represents a great threat to public health. However, owing to side
effects and the emergence of resistant virus strains, the use of currently available anti …

Initial inoculum and the severity of COVID-19: A mathematical modeling study of the dose-response of SARS-CoV-2 infections

B Fain, HM Dobrovolny - Epidemiologia, 2020 - mdpi.com
SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2) causes a variety of
responses in those who contract the virus, ranging from asymptomatic infections to acute …

Occupational management of healthcare workers exposed to COVID-19

C Ochoa-Leite, J Bento, DR Rocha… - Occupational …, 2021 - academic.oup.com
Background The year 2020 was marked by the new coronavirus pandemic, resulting in
millions of cases and deaths, placing healthcare workers at high risk of infection. Aims The …

Neutrophil-to-lymphocyte ratio as a potential biomarker in predicting influenza susceptibility

G Wang, C Lv, C Liu, W Shen - Frontiers in Microbiology, 2022 - frontiersin.org
Background Human population exposed to influenza viruses exhibited wide variation in
susceptibility. The ratio of neutrophils to lymphocytes (NLR) has been examined to be a …