Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes
Y Artemenko, TJ Lampert, PN Devreotes - Cellular and molecular life …, 2014 - Springer
Chemotaxis, or directed migration of cells along a chemical gradient, is a highly coordinated
process that involves gradient sensing, motility, and polarity. Most of our understanding of …
process that involves gradient sensing, motility, and polarity. Most of our understanding of …
Regulation of immune cell signaling by SHIP1: A phosphatase, scaffold protein, and potential therapeutic target
SD Pauls, AJ Marshall - European journal of immunology, 2017 - Wiley Online Library
The phosphoinositide phosphatase SHIP is a critical regulator of immune cell activation.
Despite considerable study, the mechanisms controlling SHIP activity to ensure balanced …
Despite considerable study, the mechanisms controlling SHIP activity to ensure balanced …
Blocking TIGIT/CD155 signalling reverses CD8+ T cell exhaustion and enhances the antitumor activity in cervical cancer
L Liu, A Wang, X Liu, S Han, Y Sun, J Zhang… - Journal of translational …, 2022 - Springer
Objective TIGIT/CD155 has attracted widespread attention as a new immune checkpoint and
a potential target for cancer immunotherapy. In our study, we evaluated the role of …
a potential target for cancer immunotherapy. In our study, we evaluated the role of …
Inhibition of PI3K signaling spurs new therapeutic opportunities in inflammatory/autoimmune diseases and hematological malignancies
The phosphoinositide 3-kinase/mammalian target of rapamycin/protein kinase B
(PI3K/mTOR/Akt) signaling pathway is central to a plethora of cellular mechanisms in a wide …
(PI3K/mTOR/Akt) signaling pathway is central to a plethora of cellular mechanisms in a wide …
Urban sanitation and the decline of mortality
B Harris, J Helgertz - The History of the Family, 2019 - Taylor & Francis
This paper introduces a special issue of The History of the Family on sanitation and urban
mortality. The special issue contains papers which focus on the impact of sanitary reforms on …
mortality. The special issue contains papers which focus on the impact of sanitary reforms on …
SHIP1 and its role for innate immune regulation—Novel targets for immunotherapy
WJ Yeoh, P Krebs - European journal of immunology, 2023 - Wiley Online Library
Abstract Phosphoinositide‐3‐kinase/AKT (PI3K/AKT) signaling plays key roles in the
regulation of cellular activity in both health and disease. In immune cells, this PI3K/AKT …
regulation of cellular activity in both health and disease. In immune cells, this PI3K/AKT …
Development of new strategy combining heat treatment and phage cocktail for post-contamination prevention
Heat treatment is an effective method for ensuring food safety and quality by controlling
microbial contamination. However, food poisoning outbreaks have continuously occurred in …
microbial contamination. However, food poisoning outbreaks have continuously occurred in …
The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions
The phosphoinositide 3-kinase (PI3K) pathway is a central signal transduction axis
controlling normal B cell homeostasis and activation in humoral immunity. The p110δ PI3K …
controlling normal B cell homeostasis and activation in humoral immunity. The p110δ PI3K …
Characterization of AQX‐1125, a small‐molecule SHIP1 activator: part 1. Effects on inflammatory cell activation and chemotaxis in vitro and pharmacokinetic …
GR Stenton, LF Mackenzie, P Tam… - British journal of …, 2013 - Wiley Online Library
Background The SH2‐containing inositol‐5′‐phosphatase 1 (SHIP1) metabolizes PI (3, 4,
5) P3 to PI (3, 4) P2. SHIP1‐deficient mice exhibit progressive inflammation …
5) P3 to PI (3, 4) P2. SHIP1‐deficient mice exhibit progressive inflammation …
The SH2-domain-containing inositol 5-phosphatase (SHIP) limits the motility of neutrophils and their recruitment to wounds in zebrafish
Neutrophil recruitment to sites of injury or infection is essential for host defense, but it needs
to be tightly regulated to prevent tissue damage. Phosphoinositide 3-kinase (PI3K), which …
to be tightly regulated to prevent tissue damage. Phosphoinositide 3-kinase (PI3K), which …