[HTML][HTML] Mesenchymal stromal cells: putative microenvironmental modulators become cell therapy
M Krampera, K Le Blanc - Cell stem cell, 2021 - cell.com
An exceptional safety profile has been shown in a large number of cell therapy clinical trials
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …
Haematopoietic stem cell activity and interactions with the niche
S Pinho, PS Frenette - Nature reviews Molecular cell biology, 2019 - nature.com
The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …
Osteoimmunology: evolving concepts in bone–immune interactions in health and disease
M Tsukasaki, H Takayanagi - Nature Reviews Immunology, 2019 - nature.com
In terrestrial vertebrates, bone tissue constitutes the 'osteoimmune'system, which functions
as a locomotor organ and a mineral reservoir as well as a primary lymphoid organ where …
as a locomotor organ and a mineral reservoir as well as a primary lymphoid organ where …
Bone marrow niches in haematological malignancies
Haematological malignancies were previously thought to be driven solely by genetic or
epigenetic lesions within haematopoietic cells. However, the niches that maintain and …
epigenetic lesions within haematopoietic cells. However, the niches that maintain and …
[HTML][HTML] A cellular taxonomy of the bone marrow stroma in homeostasis and leukemia
N Baryawno, D Przybylski, MS Kowalczyk, Y Kfoury… - Cell, 2019 - cell.com
Stroma is a poorly defined non-parenchymal component of virtually every organ with key
roles in organ development, homeostasis, and repair. Studies of the bone marrow stroma …
roles in organ development, homeostasis, and repair. Studies of the bone marrow stroma …
Adult haematopoietic stem cell niches
Stem cell niches are specialized microenvironments that promote the maintenance of stem
cells and regulate their function. Recent advances have improved our understanding of the …
cells and regulate their function. Recent advances have improved our understanding of the …
Single-cell profiling of tumour evolution in multiple myeloma—opportunities for precision medicine
Multiple myeloma (MM) is a haematological malignancy of plasma cells characterized by
substantial intraclonal genetic heterogeneity. Although therapeutic advances made in the …
substantial intraclonal genetic heterogeneity. Although therapeutic advances made in the …
Genetics of MDS
S Ogawa - Blood, The Journal of the American Society of …, 2019 - ashpublications.org
Our knowledge about the genetics of myelodysplastic syndromes (MDS) and related
myeloid disorders has been dramatically improved during the past decade, in which …
myeloid disorders has been dramatically improved during the past decade, in which …
[HTML][HTML] Inflammation-induced tumorigenesis and metastasis
S Hibino, T Kawazoe, H Kasahara, S Itoh… - International journal of …, 2021 - mdpi.com
Inflammation, especially chronic inflammation, plays a pivotal role in tumorigenesis and
metastasis through various mechanisms and is now recognized as a hallmark of cancer and …
metastasis through various mechanisms and is now recognized as a hallmark of cancer and …
Osteoimmunology: the conceptual framework unifying the immune and skeletal systems
K Okamoto, T Nakashima, M Shinohara… - Physiological …, 2017 - journals.physiology.org
The immune and skeletal systems share a variety of molecules, including cytokines,
chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune …
chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune …