Pharmacological conditioning aims to protect the heart from myocardial ischemia-
reperfusion injury (IRI). Despite extensive research in this area, today, a significant gap …

Nitric oxide (NO) is a gas that induces relaxation of smooth muscle cells in the vasculature.
Because NO reacts with oxyhaemoglobin with high affinity, the gas is rapidly scavenged by …

Inhaled nitric oxide (iNO) acts as a selective pulmonary vasodilator and it is currently
approved by the FDA for the treatment of persistent pulmonary hypertension of the newborn …

Pulmonary hypertension (PH) is a severe disease that affects people of all ages. It can occur
as an idiopathic disorder at birth or as part of a variety of cardiovascular and pulmonary …

Background: The biological effects of nitric oxide are mediated via protein S-nitrosylation.
Levels of S-nitrosylated protein are controlled in part by the denitrosylase, S …

Mild hypothermia improves survival and neurological recovery after cardiac arrest (CA) and
cardiopulmonary resuscitation (CPR). However, the mechanism underlying this …

Acute kidney injury is a common complication after cardiac surgery that is associated with
high postoperative morbidity and mortality. Levels of hemolysis are associated closely with …

Background Previous studies have identified pulmonary hypertension (PH) as a relatively
common diagnosis in children with in-hospital cardiac arrest (IHCA), and preclinical …

Introduction Inhaled nitric oxide (iNO) improves outcomes when given post systemic
ischemia/reperfusion injury. iNO given during cardiopulmonary resuscitation (CPR) may …

Objective Inhalation of noble and other gases after cardiac arrest (CA) might improve
neurological and cardiac outcomes. This article discusses up-to-date information on this …