Traumatic spinal cord injury (SCI) is a complex pathological process. The initial mechanical
damage is followed by a progressive secondary injury cascade. The injury ruptures the local …

High mobility group box 1 (HMGB1) is an extremely versatile protein that is located
predominantly in the nucleus of quiescent eukaryotic cells, where it is critically involved in …

Arteries and veins are specified by antagonistic transcriptional programs. However, during
development and regeneration, new arteries can arise from pre-existing veins through a …

Effective vascular regeneration could provide therapeutic benefit for multiple pathologies,
especially in chronic peripheral artery disease (PAD) and myocardial ischemia. The hypoxia …

Objective—In response to tissue injury, the appropriate progression of events in
angiogenesis is controlled by a careful balance between pro and antiangiogenic factors. We …

The transcriptional pathways activated downstream of vascular endothelial growth factor
(VEGF) signaling during angiogenesis remain incompletely characterized. By assessing the …

Objective: Atherosclerosis predominantly forms in regions of oscillatory shear stress while
regions of laminar shear stress are protected. This protection is partly through the …

As the primary causes of myocardial infarction, stroke, atherosclerosis, in-stent restenosis,
and aneurysm, aortic diseases pose a serious threat to human health. Arterial remodeling is …

Venous endothelial cells are molecularly and functionally distinct from their arterial
counterparts. Although veins are often considered the default endothelial state, genetic …

Abstract Notch and Angiopoietin-1 (Ang1)/Tie2 pathways are crucial for vascular maturation
and stability. Here we identify the transcription factor ERG as a key regulator of endothelial …