PART I THE ENDOTHELIUM has long been viewed as an inert cellophane-like membrane
that lines the circulatory system with its primary essential function being the maintenance of …

Chemical tools have proven indispensable for studies in glycobiology. Synthetic
oligosaccharides and glycoconjugates provide materials for correlating structure with …

Mucin-type O-glycans are the primary constituents of mucins that are expressed on various
mucosal sites of the body, especially the bacteria-laden intestinal tract. Mucins are the main …

Vestweber, Dietmar, and James E. Blanks. Mechanisms That Regulate the Function of the
Selectins and Their Ligands. Physiol. Rev. 79: 181–213, 1999.—Selectins are a family of …

Understanding the molecular basis of lymphocyte homing to lymphoid organs was originally
a problem of concern only to immunologists. With the discovery of l-selectin and its ligands …

The last 5 years have seen a marked increase in research on keratan sulfate (KS) and a
concomitant increase in our understanding of the range of molecules that carry this …

Glycoproteins with O-glycosidically linked carbohydrate chains of complex structures and
functions are found in secretions and on the cell surfaces of cancer cells. The structures of O …

Sialic acids (Sias) are terminal components of many glycoproteins and glycolipids especially
of higher animals. In this exposed position they contribute significantly to the structural …

Abstract α (1, 3) Fucosylated oligosaccharides represent components of leukocyte
counterreceptors for E-and P-selectins and of L-selectin ligands expressed by lymph node …

Heparin has been used clinically as an anticoagulant and antithrombotic agent for over 60
years. Here we show that the potent anti-inflammatory property of heparin results primarily …