Recent advances in targeted therapies in acute myeloid leukemia
Acute myeloid leukemia (AML) is the most common acute leukemia in adults. While survival
for younger patients over the last several decades has improved nearly sixfold with the …
for younger patients over the last several decades has improved nearly sixfold with the …
[HTML][HTML] Early human embryonic development: Blastocyst formation to gastrulation
J Rossant, PPL Tam - Developmental cell, 2022 - cell.com
There has been recent renewed interest in studying human early embryonic development.
The advent of improved culture conditions to maintain blastocysts in vitro for an extended …
The advent of improved culture conditions to maintain blastocysts in vitro for an extended …
Life histories of myeloproliferative neoplasms inferred from phylogenies
N Williams, J Lee, E Mitchell, L Moore, EJ Baxter… - Nature, 2022 - nature.com
Mutations in cancer-associated genes drive tumour outgrowth, but our knowledge of the
timing of driver mutations and subsequent clonal dynamics is limited,–. Here, using whole …
timing of driver mutations and subsequent clonal dynamics is limited,–. Here, using whole …
[HTML][HTML] Clonal dynamics of haematopoiesis across the human lifespan
E Mitchell, M Spencer Chapman, N Williams… - Nature, 2022 - nature.com
Age-related change in human haematopoiesis causes reduced regenerative capacity,
cytopenias, immune dysfunction and increased risk of blood cancer,–, but the reason for …
cytopenias, immune dysfunction and increased risk of blood cancer,–, but the reason for …
The longitudinal dynamics and natural history of clonal haematopoiesis
MA Fabre, JG de Almeida, E Fiorillo, E Mitchell… - Nature, 2022 - nature.com
Clonal expansions driven by somatic mutations become pervasive across human tissues
with age, including in the haematopoietic system, where the phenomenon is termed clonal …
with age, including in the haematopoietic system, where the phenomenon is termed clonal …
Extensive phylogenies of human development inferred from somatic mutations
Starting from the zygote, all cells in the human body continuously acquire mutations.
Mutations shared between different cells imply a common progenitor and are thus naturally …
Mutations shared between different cells imply a common progenitor and are thus naturally …
[HTML][HTML] Deciphering cell states and genealogies of human haematopoiesis
The human blood system is maintained through the differentiation and massive amplification
of a limited number of long-lived haematopoietic stem cells (HSCs). Perturbations to this …
of a limited number of long-lived haematopoietic stem cells (HSCs). Perturbations to this …
Genetic mosaicism in the human brain: from lineage tracing to neuropsychiatric disorders
S Bizzotto, CA Walsh - Nature Reviews Neuroscience, 2022 - nature.com
Genetic mosaicism is the result of the accumulation of somatic mutations in the human
genome starting from the first postzygotic cell generation and continuing throughout the …
genome starting from the first postzygotic cell generation and continuing throughout the …
Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia
Abstract KMT2A-rearranged infant ALL is an aggressive childhood leukemia with poor
prognosis. Here, we investigated the developmental state of KMT2A-rearranged infant B-cell …
prognosis. Here, we investigated the developmental state of KMT2A-rearranged infant B-cell …
Clonal dynamics in early human embryogenesis inferred from somatic mutation
Cellular dynamics and fate decision in early human embryogenesis remain largely unknown
owing to the challenges of performing studies in human embryos. Here, we explored whole …
owing to the challenges of performing studies in human embryos. Here, we explored whole …