Methlenetetrahydrofolate reductase (MTHFR) is one of the most important enzymes for folate
metabolism. This enzyme is mapped on chromosome 1, which is located at the end of the …

Background Folate and homocysteine are involved in DNA synthesis and methylation
processes, which are deregulated during carcinogenesis. Objectives The aim of this study …

Elevated homocysteine is a risk factor for many complex disorders. The role of
methylenetetrahydrofolate reductase (MTHFR) gene in methylation of homocysteine makes …

The association between single-nucleotide polymorphisms (SNPs) of the CYP1B1 gene and
lung cancer risk is still ambiguous. In this meta analysis, we assessed 10 case–control …

Data indicates that genetic factors alone do not account for ovarian tumorigenesis,
suggesting that epigenetic status additionally affects this process. Therefore, we assessed …

Background Cigarette smoking is an established risk factor of lung cancer development
while the current epidemiological evidence is suggestive of an increased lung cancer risk …

Folate and other B vitamins are essential co-factors of one-carbon metabolism, and genetic
variants, such as polymorphisms, can alter the metabolism. Furthermore, the adoption of …

Lung cancer is the most frequently occurring type of cancer worldwide and the leading
cause of cancer mortality. Environmental and genetic factors play important roles in lung …

Results from previous studies on the association between methylenetetrahydrofolate
reductase (MTHFR) polymorphisms C677T and A1298C and lung cancer have been …

Published studies on the relationships between 5, 10-methylenetetrahydrofolate reductase
(MTHFR) polymorphisms and lung cancer risk have been conflicting. To derive a more …