Wnt signaling regulates a variety of cellular processes, including cell fate, differentiation,
proliferation and stem cell pluripotency. Aberrant Wnt signaling is a hallmark of many …

We have greatly advanced our ability to grow a diverse range of tissue-derived and
pluripotent stem cell–derived gastrointestinal (GI) tissues in vitro. These systems, broadly …

Transposable elements (TEs) represent a substantial fraction of many eukaryotic genomes,
and transcriptional regulation of these factors is important to determine TE activities in …

Background & Aims Known genetic factors explain only a small fraction of genetic variation
in colorectal cancer (CRC). We conducted a genome-wide association study to identify risk …

Mammalian genomes harbor abundant transposable elements (TEs) and their remnants,
with numerous epigenetic repression mechanisms enacted to silence TE transcription …

Drugs that target intracellular signalling pathways have markedly improved progression-free
survival of patients with cancers who were previously regarded as untreatable. However, the …

LINE-1 (L1) is a class of autonomous mobile genetic elements that form somatic mosaicisms
in various tissues of the organism. The activity of L1 retrotransposons is strictly controlled by …

Prevalent copy number alteration is the most prominent genetic characteristic associated
with ovarian cancer (OV) development, but its role in immune evasion has not been fully …

Long interspersed nuclear element-1 (L1) retrotransposons are jumping genes that
comprise 17% of human DNA. They utilize a ''copy-and-paste''mechanism to propagate …

The cohesin complex is crucial for mediating sister chromatid cohesion and for hierarchal
three-dimensional organization of the genome. Mutations in cohesin genes are present in a …