Conditioned medium–is it an undervalued lab waste with the potential for osteoarthritis management?

MA Rosochowicz, MS Lach, M Richter… - Stem Cell Reviews and …, 2023 - Springer
Background The approaches currently used in osteoarthritis (OA) are mainly short-term
solutions with unsatisfactory outcomes. Cell-based therapies are still controversial (in terms …

[HTML][HTML] How are aging and osteoarthritis related?

S Wakale, X Wu, Y Sonar, A Sun, X Fan… - Aging and …, 2023 - ncbi.nlm.nih.gov
Osteoarthritis is the most prevalent degenerative joint disease and one of the leading
causes of physical impairment in the world's aging population. The human lifespan has …

In vitro characterization of doxorubicin-mediated stress-induced premature senescence in human chondrocytes

V Kirsch, JM Ramge, A Schoppa, A Ignatius, J Riegger - Cells, 2022 - mdpi.com
Accumulation of senescent chondrocytes is thought to drive inflammatory processes and
subsequent cartilage degeneration in age-related as well as posttraumatic osteoarthritis …

Theaflavin‐3,3 ‐Digallate Protects Cartilage from Degradation by Modulating Inflammation and Antioxidant Pathways

Y Teng, Z Jin, W Ren, M Lu, M Hou… - Oxidative Medicine …, 2022 - Wiley Online Library
Background. Osteoarthritis (OA) is a common degenerative joint disease that may be closely
linked to inflammation and oxidative stress destroying the balance of cartilage matrix …

Thermo-responsive gel containing hydroxytyrosol-chitosan nanoparticles (Hyt@ tgel) counteracts the increase of osteoarthritis biomarkers in human chondrocytes

A Valentino, R Conte, I De Luca, F Di Cristo, G Peluso… - Antioxidants, 2022 - mdpi.com
Although osteoarthritis (OA) is a chronic inflammatory degenerative disease affecting
millions of people worldwide, the current therapies are limited to palliative care and do not …

Epigenetic regulatory mechanism of ADAMTS12 expression in osteoarthritis

S Yang, X Zhou, Z Jia, M Zhang, M Yuan, Y Zhou… - Molecular …, 2023 - Springer
Background Osteoarthritis (OA) is a degenerative joint disease with lacking effective
prevention targets. A disintegrin and metalloproteinase with thrombospondin motifs 12 …

Translating osteoarthritis genetics research: challenging times ahead

J Loughlin - Trends in Molecular Medicine, 2022 - cell.com
The ultimate goal of molecular genetic studies of human diseases is to translate the
discoveries for patient benefit. For diseases that lack licensed disease-modifying …

ER stress in ERp57 knockout knee joint chondrocytes induces osteoarthritic cartilage degradation and osteophyte formation

Y Rellmann, E Eidhof, U Hansen… - International Journal of …, 2021 - mdpi.com
Ageing or obesity are risk factors for protein aggregation in the endoplasmic reticulum (ER)
of chondrocytes. This condition is called ER stress and leads to induction of the unfolded …

[HTML][HTML] Age-Associated Calcification: Insights from Murine Models

S Nasi, M Romani, N Busso - Gout, Urate, and Crystal Deposition Disease, 2024 - mdpi.com
Calcification refers to the deposition of calcium-containing crystals either intracellularly or
within the extracellular matrix. Physiologic calcification is a normal process occurring during …

Effects of glucose concentration and oxygen partial pressure on the respiratory metabolism of sheep temporomandibular joint disc cells

F Dong, P Zhang, B Ma, G Bao… - Experimental and …, 2023 - spandidos-publications.com
Temporomandibular joint (TMJ) disc degeneration is a common disease characterized by a
decrease in metabolic function. The present study aimed to investigate the pathogenesis of …