Charged and polar groups, through forming ion pairs, hydrogen bonds, and other less
specific electrostatic interactions, impart important properties to proteins. Modulation of the …

Gene-specific transcription factors (TFs) are key regulatory components of signaling
pathways, controlling, for example, cell growth, development, and stress responses. Their …

In eukaryotes, many DNA/RNA-binding proteins possess intrinsically disordered regions
(IDRs) with large negative charge, some of which involve a consecutive sequence of …

Aptamers are structured nucleic acid molecules that can bind to their targets with high affinity
and specificity. However, conventional SELEX (Systematic Evolution of Ligands by …

Zinc finger (ZnF) domains appear in a pool of structural contexts and despite their small size
achieve varying target specificities, covering single-stranded and double-stranded DNA and …

Despite their diverse biochemical characteristics and functions, all DNA-binding proteins
share the ability to accurately locate their target sites among the vast excess of non-target …

Diffusion is a pervasive process present in a broad spectrum of cellular reactions. Its
mathematical description has existed for nearly two centuries and permits the construction of …

Cre recombinase is a phage-derived enzyme that has found utility for precise manipulation
of DNA sequences. Cre recognizes and recombines pairs of loxP sequences characterized …

Poly (ADP-ribose) polymerase 1 (PARP1) is both a first responder to DNA damage and a
chromatin architectural protein. How PARP1 rapidly finds DNA damage sites in the context …

Conspectus The prospect of recreating the complex structural hierarchy of protein folding in
synthetic oligomers with backbones that are artificial in covalent structure (“foldamers”) has …