Abstract “Food addiction” has become a focus of interest for researchers attempting to
explain certain processes and/or behaviors that may contribute to the development of …

Vastly stimulated by the discovery of opioid receptors in the early 1970s, preclinical and
clinical research was directed at the study of stereoselective neuronal actions of opioids …

Glial activation participates in the mediation of pain including neuropathic pain, due to
release of neuroexcitatory, proinflammatory products. Glial activation is now known to occur …

Opioid receptors (OR) are part of the class A of G-protein coupled receptors and the target of
the opiates, the most powerful analgesic molecules used in clinic. During a protracted use, a …

The use of opioids for the treatment of chronic pain has increased dramatically over the past
decade. Whether these drugs provide considerable benefits in terms of pain reduction and …

Morphine exhibits important pharmacological effects for which it has been used in medical
practice for quite a long time. However, it has a high addictive potential and can be abused …

The development of opioid-induced analgesic tolerance and hyperalgesia is a clinical
challenge for managing chronic pain. Adaptive changes in protein translation in the nervous …

Chronic pain is among the most disabling and costly disorders, with prevalence ranging
from 10% to 55%. However, current therapeutic strategies for chronic pain are unsatisfactory …

Chronic opioid therapy in the treatment of chronic nonmalignant pain has increased
drastically over the past decade. This is a worrisome trend in general, but specifically, given …

BACKGROUND AND PURPOSE Opiates remain the most effective compounds for
alleviating severe pain across a wide range of conditions. However, their use is associated …