[HTML][HTML] Lyotropic liquid crystals for parenteral drug delivery

VP Chavda, S Dawre, A Pandya, LK Vora… - Journal of Controlled …, 2022 - Elsevier
The necessity for long-term treatments of chronic diseases has encouraged the
development of novel long-acting parenteral formulations intending to improve drug …

Lyotropic liquid crystalline phases: drug delivery and biomedical applications

VP Chavda, S Dyawanapelly, S Dawre… - International Journal of …, 2023 - Elsevier
Liquid crystal (LC)-based nanoformulations may efficiently deliver drugs and therapeutics to
targeted biological sites. Lyotropic liquid crystalline phases (LLCPs) have received much …

Optimization of curcumin nanofibers as fast dissolving oral films prepared by emulsion electrospinning via central composite design

H Kamali, P Farzadnia, J Movaffagh… - Journal of Drug Delivery …, 2022 - Elsevier
The pharmacological beneficial effects of curcumin (CUR) are compromised by its water
insolubility, poor bioavailability, and instability. The fast-dissolving oral films prepared by …

Recent Advances in the Development of Liquid Crystalline Nanoparticles as Drug Delivery Systems

JSL Leu, JJX Teoh, ALQ Ling, J Chong, YS Loo… - Pharmaceutics, 2023 - mdpi.com
Due to their distinctive structural features, lyotropic nonlamellar liquid crystalline
nanoparticles (LCNPs), such as cubosomes and hexosomes, are considered effective drug …

Prolonged local delivery of doxorubicin to cancer cells using lipid liquid crystalline system

M Karimi, H Kamali, S Fakhrmohammadi… - International Journal of …, 2023 - Elsevier
Exploring efficient strategies to eradicate the tumor tissue and enhance patient outcomes
still remained a serious challenge. Systemic toxicity of the current chemotherapeutics and …

Injectable In-Situ Forming Depot Based on PLGA and PLGA-PEG-PLGA for Sustained-Release of Risperidone: In Vitro Evaluation and Pharmacokinetics in Rabbits

SN Rezaeian Shiadeh, F Hadizadeh, E Khodaverdi… - Pharmaceutics, 2023 - mdpi.com
In the current research, novel drug delivery systems based on in situ forming gel
(ISFG)(PLGA-PEG-PLGA) and in situ forming implant (ISFI)(PLGA) were developed for one …

In-vitro and in-vivo evaluation of sustained-release buprenorphine using in-situ forming lipid-liquid crystal gels

E Khodaverdi, F Hadizadeh, N Hoseini, F Eisvand… - Life Sciences, 2023 - Elsevier
Aims Sustained-release systems reduce the incidence of drug side effects and the need for
frequent drug consumption, thus increasing patient compliance with treatment. In this study …

Preparation and characterization of injectable in-situ forming gel based on lipid liquid crystal for one month delivery of aripiprazole: In-vitro and in-vivo evaluations in …

M Karimi, S Azimi-Hashemi, E Khodaverdi… - Journal of Drug Delivery …, 2024 - Elsevier
The present study developed a one-month sustained-release formulation of aripiprazole,
used for the treatment of schizophrenia and bipolar disorder, based on lipid liquid crystal …

Development of Sustained Release Formulations Based on Lipid-Liquid Crystal to Control the Release of Deoxycholate: In Vitro and In Vivo Assessment

M Kouhjani, A Saberi, F Hadizadeh, E Khodaverdi… - AAPS …, 2023 - Springer
Subcutaneous injections of phosphatidylcholine (PC), sodium deoxycholate (NADC), and a
mixture of them were found to be an effective option for treating cellulite. However, it is …

Construction and evaluation of a phospholipid-based phase transition in situ gel system for brexpiprazole

R Tao, L Liu, Y Xiong, Q Zhang, X Lv, L He… - Drug Delivery and …, 2023 - Springer
The objective of this study was to develop phospholipid-based injectable phase transition in
situ gels (PTIGs) for the sustained release of Brexpiprazole (Brex). Phospholipid (Lipoid …