The recent focus of federal funding on comparative effectiveness research underscores the
importance of clinical trials in the practice of evidence-based medicine and health care …

In almost all controlled trials treatments are allocated by randomisation. Blocking and
stratification can be used to ensure balance between groups in size and patient …

Importance Suicide is a leading cause of death among 10-to 24-year-old individuals in the
United States; evidence on effective treatment for adolescents who engage in suicidal and …

Background Primary angle-closure glaucoma is a leading cause of irreversible blindness
worldwide. In early-stage disease, intraocular pressure is raised without visual loss …

Purpose We evaluated the effectiveness of a low-intensity, home-based physical activity
program (Onco-Move) and a moderate-to high-intensity, combined supervised resistance …

Music has been identified as a strength in people with Autism Spectrum Disorder; however,
there is currently no neuroscientific evidence supporting its benefits. Given its universal …

Background Pretreatment with anti-thymocyte globulin (ATG) decreases the occurrence of
chronic graft-versus-host disease (CGVHD) after haemopoietic cell transplantation from an …

Background Adjustment for prognostic covariates can lead to increased power in the
analysis of randomized trials. However, adjusted analyses are not often performed in …

We present new evidence on the randomization methods used in existing experiments, and
new simulations comparing these methods. We find that many papers do not describe the …

The purpose of this work was to determine the effects of varying levels of dietary protein on
body composition and muscle protein synthesis during energy deficit (ED). A randomized …