The term non-alcoholic fatty liver disease (NAFLD), and its definition, have limitations for
both adults and children. The definition is most problematic for children, for whom alcohol …

The metabolic syndrome, by definition, is not a disease but is a clustering of individual
metabolic risk factors including abdominal obesity, hyperglycemia, hypertriglyceridemia …

Abstract Introduction The Metabolic Syndrome (MetS) describes the clustering of cardio-
metabolic risk factors—including abdominal obesity, insulin resistance, elevated blood …

The prevalence of obesity has increased worldwide over the past few decades. In 2013, the
prevalence of obesity exceeded the 50% of the adult population in some countries from …

Abstract Purpose of Review This review summarizes our current understanding of the
metabolic syndrome (MetS) in children and adolescents. Special emphasis is given towards …

Emerging evidence has assigned an important role to sleep as a modulator of metabolic
homeostasis. The impact of variations in sleep duration, sleep-disordered breathing, and …

1704 Circulation Research May 27, 2016 of epigenetic mechanisms contributing to
macrovascular disease in diabetes. The authors highlight the recent identification of …

Childhood obesity has high societal and economic impact but current treatment approaches
are sub-optimal. In the last decade, important studies have been conducted aiming to …

Metabolic syndrome (MetS) is recognized as an escalating major health risk in adults as well
as in children and adolescents. Its prevalence ranges from 6 to 39% depending on the …

Insufficient sleep, which has become endemic in recent years, has been variably associated
with increased risk of obesity, disorders of glucose and insulin homeostasis, and the …