[HTML][HTML] Microbial communication leading to the activation of silent fungal secondary metabolite gene clusters
T Netzker, J Fischer, J Weber, DJ Mattern… - Frontiers in …, 2015 - frontiersin.org
Microorganisms form diverse multispecies communities in various ecosystems. The high
abundance of fungal and bacterial species in these consortia results in specific …
abundance of fungal and bacterial species in these consortia results in specific …
Strategies for mining fungal natural products
Fungi are well known for their ability to produce a multitude of natural products. On the one
hand their potential to provide beneficial antibiotics and immunosuppressants has been …
hand their potential to provide beneficial antibiotics and immunosuppressants has been …
[HTML][HTML] The Fusarium graminearum Histone H3 K27 Methyltransferase KMT6 Regulates Development and Expression of Secondary Metabolite Gene Clusters
LR Connolly, KM Smith, M Freitag - PLoS genetics, 2013 - journals.plos.org
The cereal pathogen Fusarium graminearum produces secondary metabolites toxic to
humans and animals, yet coordinated transcriptional regulation of gene clusters remains …
humans and animals, yet coordinated transcriptional regulation of gene clusters remains …
Heterochromatic marks are associated with the repression of secondary metabolism clusters in Aspergillus nidulans
Y Reyes‐Dominguez, JW Bok, H Berger… - Molecular …, 2010 - Wiley Online Library
Fungal secondary metabolites are important bioactive compounds but the conditions
leading to expression of most of the putative secondary metabolism (SM) genes predicted by …
leading to expression of most of the putative secondary metabolism (SM) genes predicted by …
[HTML][HTML] Epigenetic Control of Effector Gene Expression in the Plant Pathogenic Fungus Leptosphaeria maculans
JL Soyer, M El Ghalid, N Glaser, B Ollivier… - PLoS …, 2014 - journals.plos.org
Plant pathogens secrete an arsenal of small secreted proteins (SSPs) acting as effectors that
modulate host immunity to facilitate infection. SSP-encoding genes are often located in …
modulate host immunity to facilitate infection. SSP-encoding genes are often located in …
Secondary metabolism in fungi: does chromosomal location matter?
Filamentous fungi produce a vast array of small molecules called secondary metabolites,
which include toxins as well as antibiotics. Coregulated gene clusters are the hallmark of …
which include toxins as well as antibiotics. Coregulated gene clusters are the hallmark of …
Compartmentalization and molecular traffic in secondary metabolism: a new understanding of established cellular processes
Great progress has been made in understanding the regulation of expression of genes
involved in secondary metabolism. Less is known about the mechanisms that govern the …
involved in secondary metabolism. Less is known about the mechanisms that govern the …
[HTML][HTML] The chromatin code of fungal secondary metabolite gene clusters
A Gacek, J Strauss - Applied Microbiology and Biotechnology, 2012 - Springer
Secondary metabolite biosynthesis genes in fungi are usually physically linked and
organized in large gene clusters. The physical linkage of genes involved in the same …
organized in large gene clusters. The physical linkage of genes involved in the same …
[HTML][HTML] Aspergillus fumigatus copper export machinery and reactive oxygen intermediate defense counter host copper-mediated oxidative antimicrobial offense
The Fenton-chemistry-generating properties of copper ions are considered a potent
phagolysosome defense against pathogenic microbes, yet our understanding of underlying …
phagolysosome defense against pathogenic microbes, yet our understanding of underlying …
Toward awakening cryptic secondary metabolite gene clusters in filamentous fungi
Mining for novel natural compounds is of eminent importance owing to the continuous need
for new pharmaceuticals. Filamentous fungi are historically known to harbor the genetic …
for new pharmaceuticals. Filamentous fungi are historically known to harbor the genetic …