[HTML][HTML] Pharmacological modulation of ubiquitin-proteasome pathways in oncogenic signaling
The ubiquitin-proteasome pathway (UPP) is involved in regulating several biological
functions, including cell cycle control, apoptosis, DNA damage response, and apoptosis. It is …
functions, including cell cycle control, apoptosis, DNA damage response, and apoptosis. It is …
[HTML][HTML] The many substrates and functions of NEDD4-1
X Huang, J Chen, W Cao, L Yang, Q Chen, J He… - Cell death & …, 2019 - nature.com
Tumorigenesis, tumor growth, and prognosis are highly related to gene alterations and post-
translational modifications (PTMs). Ubiquitination is a critical PTM that governs practically all …
translational modifications (PTMs). Ubiquitination is a critical PTM that governs practically all …
[HTML][HTML] The effects of epithelial–mesenchymal transitions in COPD induced by cigarette smoke: an update
X Su, W Wu, Z Zhu, X Lin, Y Zeng - Respiratory research, 2022 - Springer
Cigarette smoke is a complex aerosol containing a large number of compounds with a
variety of toxicity and carcinogenicity. Long-term exposure to cigarette smoke significantly …
variety of toxicity and carcinogenicity. Long-term exposure to cigarette smoke significantly …
[HTML][HTML] A novel lncRNA, LINC00460, affects cell proliferation and apoptosis by regulating KLF2 and CUL4A expression in colorectal cancer
Y Lian, C Yan, H Xu, J Yang, Y Yu, J Zhou, Y Shi… - … Therapy-Nucleic Acids, 2018 - cell.com
Emerging evidence has proven that long noncoding RNAs (lncRNAs) play important roles in
human colorectal cancer (CRC) biology, although few lncRNAs have been characterized in …
human colorectal cancer (CRC) biology, although few lncRNAs have been characterized in …
Discovery of a novel DCAF1 ligand using a drug–target interaction prediction model: generalizing machine learning to new drug targets
SW Kimani, J Owen, SR Green, F Li, Y Li… - Journal of Chemical …, 2023 - ACS Publications
DCAF1 functions as a substrate recruitment subunit for the RING-type CRL4DCAF1 and the
HECT family EDVPDCAF1 E3 ubiquitin ligases. The WDR domain of DCAF1 serves as a …
HECT family EDVPDCAF1 E3 ubiquitin ligases. The WDR domain of DCAF1 serves as a …
[HTML][HTML] Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo
MJ Mittenbühler, K Saedler, H Nolte, L Kern, J Zhou… - Molecular …, 2020 - Elsevier
Objective Single-nucleotide polymorphisms in the FTO gene encoding an m 6 Am and an m
6 A demethylase are associated with obesity. Moreover, recent studies have linked a …
6 A demethylase are associated with obesity. Moreover, recent studies have linked a …
[HTML][HTML] Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair
Pathway choice within DNA double-strand break (DSB) repair is a tightly regulated process
to maintain genome integrity. RECQL4, deficient in Rothmund-Thomson Syndrome …
to maintain genome integrity. RECQL4, deficient in Rothmund-Thomson Syndrome …
[HTML][HTML] Cullin E3 ligases and their rewiring by viral factors
The ability of viruses to subvert host pathways is central in disease pathogenesis. Over the
past decade, a critical role for the Ubiquitin Proteasome System (UPS) in counteracting host …
past decade, a critical role for the Ubiquitin Proteasome System (UPS) in counteracting host …
[HTML][HTML] Genome-wide RNAi screening identifies protein modules required for 40S subunit synthesis in human cells
L Badertscher, T Wild, C Montellese, LT Alexander… - Cell reports, 2015 - cell.com
Ribosome biogenesis is a highly complex process requiring many assisting factors. Studies
in yeast have yielded comprehensive knowledge of the cellular machinery involved in this …
in yeast have yielded comprehensive knowledge of the cellular machinery involved in this …
Stress-induced reduction of Na+/H+ exchanger isoform 1 promotes maladaptation of neuroplasticity and exacerbates depressive behaviors
Y Li, C Fan, C Wang, L Wang, Y Yi, X Mao, X Chen… - Science …, 2022 - science.org
Major depression disorder (MDD) is a neuropsychiatric disorder characterized by abnormal
neuronal activity in specific brain regions. A factor that is crucial in maintaining normal …
neuronal activity in specific brain regions. A factor that is crucial in maintaining normal …