Brain borders at the central stage of neuroimmunology

J Rustenhoven, J Kipnis - Nature, 2022 - nature.com
The concept of immune privilege suggests that the central nervous system is isolated from
the immune system. However, recent studies have highlighted the borders of the central …

Cytokines as emerging regulators of central nervous system synapses

F Zipp, S Bittner, DP Schafer - Immunity, 2023 - cell.com
Cytokines are key messengers by which immune cells communicate, and they drive many
physiological processes, including immune and inflammatory responses. Early discoveries …

Role of regulatory non-coding RNAs in traumatic brain injury

S Li, N Qiu, A Ni, MH Hamblin, KJ Yin - Neurochemistry international, 2024 - Elsevier
Traumatic brain injury (TBI) is a potentially fatal health event that cannot be predicted in
advance. After TBI occurs, it can have enduring consequences within both familial and …

Patterns of synaptic loss in human amyotrophic lateral sclerosis spinal cord: a clinicopathological study

O Aousji, S Feldengut, S Antonucci, M Schön… - Acta Neuropathologica …, 2023 - Springer
Abstract Amyotrophic Lateral Sclerosis (ALS) is mainly characterized by the degeneration of
corticospinal neurons and spinal α-motoneurons; vulnerable cells display prominent pTDP …

Type 2 immunity in the brain and brain borders

T Mamuladze, J Kipnis - Cellular & Molecular Immunology, 2023 - nature.com
Recent research in neuroimmunology has revolutionized our understanding of the intricate
interactions between the immune system and the central nervous system (CNS). The CNS …

[HTML][HTML] Shared inflammatory glial cell signature after stab wound injury, revealed by spatial, temporal, and cell-type-specific profiling of the murine cerebral cortex

C Koupourtidou, V Schwarz, H Aliee, S Frerich… - Nature …, 2024 - nature.com
Traumatic brain injury leads to a highly orchestrated immune-and glial cell response
partially responsible for long-lasting disability and the development of secondary …

Targeting pyroptosis with nanoparticles to alleviate neuroinflammatory for preventing secondary damage following traumatic brain injury

X Zhang, X Huang, D Hang, J Jin, S Li, Y Zhu… - Science Advances, 2024 - science.org
Posttraumatic neuroinflammation is a key driver of secondary injury after traumatic brain
injury (TBI). Pyroptosis, a proinflammatory form of programmed cell death, considerably …

Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior

JJ Barron, NM Mroz, SE Taloma, MW Dahlgren… - Science, 2024 - science.org
The innate immune system shapes brain development and is implicated in
neurodevelopmental diseases. It is critical to define the relevant immune cells and signals …

Analytically controlling the laser-induced electron phase in sub-cycle motion

DA Trieu, TTD Nguyen, TDD Nguyen, T Tran, VH Le… - Physical Review A, 2024 - APS
We develop an approach to directly control the phase of an electron's sub-cycle motion in an
intense laser field. The method is established by tuning a low-frequency electric field applied …

Shank2 identifies a subset of glycinergic neurons involved in altered nociception in an autism model

F Olde Heuvel, N Ouali Alami, O Aousji… - Molecular Autism, 2023 - Springer
Abstract Background Autism Spectrum Disorders (ASD) patients experience disturbed
nociception in the form of either hyposensitivity to pain or allodynia. A substantial amount of …