The functional universe of membrane contact sites

WA Prinz, A Toulmay, T Balla - Nature reviews Molecular cell biology, 2020 - nature.com
Organelles compartmentalize eukaryotic cells, enhancing their ability to respond to
environmental and developmental changes. One way in which organelles communicate and …

Lipid transfer proteins: the lipid commute via shuttles, bridges and tubes

LH Wong, AT Gatta, TP Levine - Nature reviews Molecular cell biology, 2019 - nature.com
Lipids are distributed in a highly heterogeneous fashion in different cellular membranes.
Only a minority of lipids achieve their final intracellular distribution through transport by …

In situ architecture of the ER–mitochondria encounter structure

MR Wozny, A Di Luca, DR Morado, A Picco, R Khaddaj… - Nature, 2023 - nature.com
The endoplasmic reticulum and mitochondria are main hubs of eukaryotic membrane
biogenesis that rely on lipid exchange via membrane contact sites,–, but the underpinning …

Golgi-derived PI (4) P-containing vesicles drive late steps of mitochondrial division

S Nagashima, LC Tábara, L Tilokani, V Paupe… - Science, 2020 - science.org
Mitochondrial plasticity is a key regulator of cell fate decisions. Mitochondrial division
involves Dynamin-related protein-1 (Drp1) oligomerization, which constricts membranes at …

Mechanisms of nonvesicular lipid transport

KM Reinisch, WA Prinz - Journal of Cell Biology, 2021 - rupress.org
We have long known that lipids traffic between cellular membranes via vesicles but have
only recently appreciated the role of nonvesicular lipid transport. Nonvesicular transport can …

Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate

J Moser von Filseck, A Čopič, V Delfosse, S Vanni… - Science, 2015 - science.org
In eukaryotic cells, phosphatidylserine (PS) is synthesized in the endoplasmic reticulum
(ER) but is highly enriched in the plasma membrane (PM), where it contributes negative …

Endoplasmic reticulum–plasma membrane contact sites

Y Saheki, P De Camilli - Annual review of biochemistry, 2017 - annualreviews.org
The endoplasmic reticulum (ER) has a broad localization throughout the cell and forms
direct physical contacts with all other classes of membranous organelles, including the …

STARD 3 mediates endoplasmic reticulum‐to‐endosome cholesterol transport at membrane contact sites

LP Wilhelm, C Wendling, B Védie, T Kobayashi… - The EMBO …, 2017 - embopress.org
St AR‐related lipid transfer domain‐3 (STARD 3) is a sterol‐binding protein that creates
endoplasmic reticulum (ER)–endosome contact sites. How this protein, at the crossroad …

The receptor kinase FERONIA regulates phosphatidylserine localization at the cell surface to modulate ROP signaling

M Smokvarska, V Bayle, L Maneta-Peyret… - Science …, 2023 - science.org
Cells maintain a constant dialog between the extracellular matrix and their plasma
membrane to fine tune signal transduction processes. We found that the receptor kinase …

ORP5/ORP8 localize to endoplasmic reticulum–mitochondria contacts and are involved in mitochondrial function

R Galmes, A Houcine, AR van Vliet, P Agostinis… - EMBO …, 2016 - embopress.org
The oxysterol‐binding protein (OSBP)‐related proteins ORP 5 and ORP 8 have been shown
recently to transport phosphatidylserine (PS) from the endoplasmic reticulum (ER) to the …