The functional universe of membrane contact sites
WA Prinz, A Toulmay, T Balla - Nature reviews Molecular cell biology, 2020 - nature.com
Organelles compartmentalize eukaryotic cells, enhancing their ability to respond to
environmental and developmental changes. One way in which organelles communicate and …
environmental and developmental changes. One way in which organelles communicate and …
Lipid transfer proteins: the lipid commute via shuttles, bridges and tubes
Lipids are distributed in a highly heterogeneous fashion in different cellular membranes.
Only a minority of lipids achieve their final intracellular distribution through transport by …
Only a minority of lipids achieve their final intracellular distribution through transport by …
In situ architecture of the ER–mitochondria encounter structure
The endoplasmic reticulum and mitochondria are main hubs of eukaryotic membrane
biogenesis that rely on lipid exchange via membrane contact sites,–, but the underpinning …
biogenesis that rely on lipid exchange via membrane contact sites,–, but the underpinning …
Golgi-derived PI (4) P-containing vesicles drive late steps of mitochondrial division
Mitochondrial plasticity is a key regulator of cell fate decisions. Mitochondrial division
involves Dynamin-related protein-1 (Drp1) oligomerization, which constricts membranes at …
involves Dynamin-related protein-1 (Drp1) oligomerization, which constricts membranes at …
Mechanisms of nonvesicular lipid transport
KM Reinisch, WA Prinz - Journal of Cell Biology, 2021 - rupress.org
We have long known that lipids traffic between cellular membranes via vesicles but have
only recently appreciated the role of nonvesicular lipid transport. Nonvesicular transport can …
only recently appreciated the role of nonvesicular lipid transport. Nonvesicular transport can …
Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate
In eukaryotic cells, phosphatidylserine (PS) is synthesized in the endoplasmic reticulum
(ER) but is highly enriched in the plasma membrane (PM), where it contributes negative …
(ER) but is highly enriched in the plasma membrane (PM), where it contributes negative …
Endoplasmic reticulum–plasma membrane contact sites
Y Saheki, P De Camilli - Annual review of biochemistry, 2017 - annualreviews.org
The endoplasmic reticulum (ER) has a broad localization throughout the cell and forms
direct physical contacts with all other classes of membranous organelles, including the …
direct physical contacts with all other classes of membranous organelles, including the …
STARD 3 mediates endoplasmic reticulum‐to‐endosome cholesterol transport at membrane contact sites
LP Wilhelm, C Wendling, B Védie, T Kobayashi… - The EMBO …, 2017 - embopress.org
St AR‐related lipid transfer domain‐3 (STARD 3) is a sterol‐binding protein that creates
endoplasmic reticulum (ER)–endosome contact sites. How this protein, at the crossroad …
endoplasmic reticulum (ER)–endosome contact sites. How this protein, at the crossroad …
The receptor kinase FERONIA regulates phosphatidylserine localization at the cell surface to modulate ROP signaling
M Smokvarska, V Bayle, L Maneta-Peyret… - Science …, 2023 - science.org
Cells maintain a constant dialog between the extracellular matrix and their plasma
membrane to fine tune signal transduction processes. We found that the receptor kinase …
membrane to fine tune signal transduction processes. We found that the receptor kinase …
ORP5/ORP8 localize to endoplasmic reticulum–mitochondria contacts and are involved in mitochondrial function
R Galmes, A Houcine, AR van Vliet, P Agostinis… - EMBO …, 2016 - embopress.org
The oxysterol‐binding protein (OSBP)‐related proteins ORP 5 and ORP 8 have been shown
recently to transport phosphatidylserine (PS) from the endoplasmic reticulum (ER) to the …
recently to transport phosphatidylserine (PS) from the endoplasmic reticulum (ER) to the …