Autophagy and apoptosis play crucial roles in tumorigenesis. Recent studies have shown
that autophagy and apoptosis have a cross-talk relationship in anti-tumor therapy. It is well …

Overproduction of free radicals can damage cellular components resulting in progressive
physiological dysfunction, which has been implicated in many human diseases. Oxidative …

In recent years we have witnessed a major interest in the study of the role of mitochondria,
not only as ATP producers through oxidative phosphorylation but also as regulators of …

Heat shock proteins (Hsp) form the most ancient defense system in all living organisms on
earth. These proteins act as molecular chaperones by helping in the refolding of misfolded …

Mitochondrial dysfunction has been implicated as a contributing factor in diverse acute and
chronic neurological disorders. However, its role in the epilepsies has only recently …

Epilepsy is a common, chronic neurologic disorder characterized by recurrent unprovoked
seizures. Experimental modeling and clinical neuroimaging of patients has shown that …

The importance of calcium overload, mitochondrial dysfunction, and free radical generation
to neuropathological processes has been recognized for many years. Only more recently …

Status epilepticus (SE)-induced neuronal death is morphologically necrotic and is initiated
by excessive glutamate release, which activates postsynaptic N-methyl-d-aspartate (NMDA) …

Though succinate accumulation is associated with reactive oxygen species (ROS)
production and neuronal injury, which play critical roles in epilepsy, it is unclear whether …

Neuronal cell death is a key feature of both normal nervous system development and
neuropathological conditions. The Bcl-2 family, via its regulation of both caspase-dependent …