Microfluidics for drug development: from synthesis to evaluation

Y Liu, L Sun, H Zhang, L Shang, Y Zhao - Chemical reviews, 2021 - ACS Publications
Drug development is a long process whose main content includes drug synthesis, drug
delivery, and drug evaluation. Compared with conventional drug development procedures …

The past, present and potential for microfluidic reactor technology in chemical synthesis

KS Elvira, XC i Solvas, RCR Wootton, AJ Demello - Nature chemistry, 2013 - nature.com
The past two decades have seen far-reaching progress in the development of microfluidic
systems for use in the chemical and biological sciences. Here we assess the utility of …

Flash chemistry: flow chemistry that cannot be done in batch

J Yoshida, Y Takahashi, A Nagaki - Chemical communications, 2013 - pubs.rsc.org
Flash chemistry based on high-resolution reaction time control using flow microreactors
enables chemical reactions that cannot be done in batch and serves as a powerful tool for …

Control and detection of chemical reactions in microfluidic systems

AJ Demello - Nature, 2006 - nature.com
Recent years have seen considerable progress in the development of microfabricated
systems for use in the chemical and biological sciences. Much development has been …

Microfluidic manipulation by spiral hollow-fibre actuators

S Li, R Zhang, G Zhang, L Shuai, W Chang… - Nature …, 2022 - nature.com
A microfluidic manipulation system that can sense a liquid and control its flow is highly
desirable. However, conventional sensors and motors have difficulty fitting the limited space …

A review of microfluidic experimental designs for nanoparticle synthesis

AG Niculescu, DE Mihaiescu… - International Journal of …, 2022 - mdpi.com
Microfluidics is defined as emerging science and technology based on precisely
manipulating fluids through miniaturized devices with micro-scale channels and chambers …

Industrial lab-on-a-chip: Design, applications and scale-up for drug discovery and delivery

GT Vladisavljević, N Khalid, MA Neves… - Advanced drug delivery …, 2013 - Elsevier
Microfluidics is an emerging and promising interdisciplinary technology which offers
powerful platforms for precise production of novel functional materials (eg, emulsion …

Green and sustainable chemical synthesis using flow microreactors

J Yoshida, H Kim, A Nagaki - ChemSusChem, 2011 - Wiley Online Library
Several features that allow flow microreactors contribute to green and sustainable chemical
synthesis are presented:(1) For extremely fast reactions, kinetics often cannot be used …

Optical sensing systems for microfluidic devices: a review

B Kuswandi, J Huskens, W Verboom - Analytica chimica acta, 2007 - Elsevier
This review deals with the application of optical sensing systems for microfluidic devices. In
the “off-chip approach” macro-scale optical infrastructure is coupled, while the “on-chip …

Accelerated bimolecular reactions in microdroplets studied by desorption electrospray ionization mass spectrometry

M Girod, E Moyano, DI Campbell, RG Cooks - Chemical Science, 2011 - pubs.rsc.org
Functional group derivatization reactions occur in the course of microdroplet/surface
collisions in the ambient ionization process of desorption electrospray ionization (DESI). The …