Reactive oxygen species (ROS) are highly reactive oxygen-containing molecules generated
as natural byproducts during cellular processes, including metabolism. Under normal …

Metastatic melanoma is among the most enigmatic advanced cancers to clinically manage
despite immense progress in the way of available therapeutic options and historic …

Treatment options for patients with NRAS-mutant melanoma are limited and lack an efficient
targeted drug combination that significantly increases overall and progression-free survival …

Metastatic melanoma is either intrinsically resistant or rapidly acquires resistance to targeted
therapy treatments, such as MAPK inhibitors (MAPKi). A leading cause of resistance to …

Simple Summary Precision oncology is emerging as a viable option to improve survival in
patients who fail to remain disease-free even after the employment of currently available …

Upregulation of mitochondrial respiration coupled with high ROS-scavenging capacity is a
characteristic shared by drug-tolerant cells in several cancers. As translational fidelity is …

Simple Summary This study explores the therapeutic effect of the combination of BRAF and
MEK inhibitors (BRAFi+ MEKi) on NRAS-mutated melanomas in vitro, in preclinical in vivo …

The importance of distinguishing technologies based on the flow of information from
exploration to actuation puts forth a framework that allows the clinicians to better adapt a …

Summary Three-dimensional (3D) models play an increasingly important role in preclinical
drug testing as they faithfully mimic interactions between cancer cells and the tumor …

Upregulation of mitochondrial respiration coupled with high ROS-scavenging capacity is a
characteristic shared by drug-tolerant cells in several cancers. As translational fidelity is …