Therapeutic Potential of Aptamer–Protein Interactions

AS Shraim, BA Abdel Majeed… - ACS Pharmacology & …, 2022 - ACS Publications
Aptamers are single-stranded oligonucleotides (RNA or DNA) with a typical length between
25 and 100 nucleotides which fold into three-dimensional structures capable of binding to …

DNA-based nanomaterials as drug delivery platforms for increasing the effect of drugs in tumors

AN Shishparenok, VV Furman, DD Zhdanov - Cancers, 2023 - mdpi.com
Simple Summary The use of drugs based on nucleic acids is a promising direction in
antitumor therapy. Some modified oligonucleotide analogs, such as antisense …

Hitting the diagnostic sweet spot: Point-of-care SARS-CoV-2 salivary antigen testing with an off-the-shelf glucometer

NK Singh, P Ray, AF Carlin, C Magallanes… - Biosensors and …, 2021 - Elsevier
Significant barriers to the diagnosis of latent and acute SARS-CoV-2 infection continue to
hamper population-based screening efforts required to contain the COVID-19 pandemic in …

KIT mutations and expression: current knowledge and new insights for overcoming IM resistance in GIST

S Zhou, O Abdihamid, F Tan, H Zhou, H Liu, Z Li… - Cell Communication and …, 2024 - Springer
Gastrointestinal stromal tumor (GIST) is the most common sarcoma located in
gastrointestinal tract and derived from the interstitial cell of Cajal (ICC) lineage. Both ICC …

Enhanced Electrochemical Biosensing of the Sp17 Cancer Biomarker in Serum Samples via Engineered Two-Dimensional MoS2 Nanosheets on the Reduced …

AK Yadav, D Verma, PR Solanki - ACS Applied Bio Materials, 2023 - ACS Publications
In the present investigation, we reported a label-free and highly effective immunosensor for
the first time employing a nanostructured molybdenum disulfide nanosheets@ reduced …

Anti-KIT DNA aptamer-conjugated porous silicon nanoparticles for the targeted detection of gastrointestinal stromal tumors

S Vijayakumar, SH Nasr, JE Davis, E Wang… - Nanoscale, 2022 - pubs.rsc.org
Evaluation of Gastrointestinal Stromal Tumors (GIST) during initial clinical staging, surgical
intervention, and postoperative management can be challenging. Current imaging …

Development of a soluble KIT electrochemical aptasensor for cancer theranostics

S Chung, JK Sicklick, P Ray, DA Hall - ACS sensors, 2021 - ACS Publications
An electrochemical sensor based on a conformation-changing aptamer is reported to detect
soluble KIT, a cancer biomarker, in human serum. The sensor was fabricated with a …

Aptamer-based technology for gastric cancer theranostics

QY Lv, HF Cui, X Song - Analytical Methods, 2023 - pubs.rsc.org
Gastric cancer is one of the most common causes of cancer death worldwide. This cancer
exhibits high molecular and phenotype heterogeneity. The overall survival rate for gastric …

IgA autoantibodies target pulmonary surfactant in patients with severe COVID-19

T Sinnberg, C Lichtensteiger, OH Ali, OT Pop, M Gilardi… - medRxiv, 2021 - medrxiv.org
Complications affecting the lung are hallmarks of severe coronavirus disease 2019 (COVID-
19). While there is evidence for autoimmunity in severe COVID-19, the exact mechanisms …

Nucleic acid covalent tags

M Su, T Peng, Y Zhu, J Li - ChemBioChem - Wiley Online Library
The selective and site‐specific chemical labeling of proteins has emerged as a pivotal
research area in chemical biology and cell biology. An effective protein labeling typically …