Ischemic heart disease (IHD) is the leading cause of disability and mortality worldwide.
Reactive oxygen species (ROS) have been shown to play key roles in the progression of …

The field of cardiac tissue engineering has made significant strides over the last few
decades, highlighted by the development of human cell derived constructs that have shown …

Background: Here, we generated human cardiac muscle patches (hCMPs) of clinically
relevant dimensions (4 cm× 2 cm× 1.25 mm) by suspending cardiomyocytes, smooth muscle …

Despite increased use of human induced pluripotent stem cell-derived cardiomyocytes
(hiPSC-CMs) for drug development and disease modeling studies, methods to generate …

Some of the most significant leaps in the history of modern civilization—the development of
article in China, the steam engine, which led to the European industrial revolution, and the …

Tissue engineers and stem cell biologists have made exciting progress toward creating
simplified models of human heart muscles or aligned monolayers to help bridge a …

For the past decades, heart diseases remain the leading cause of death worldwide. In the
adult mammalian heart, damaged cardiomyocytes will be replaced by non-contractile fibrotic …

Despite the ubiquitous importance of cell contact guidance, the signal-inducing contact
guidance of mammalian cells in an aligned fibril network has defied elucidation. This is due …

Engineering of three-dimensional (3D) tissues is a promising approach for restoring
diseased or dysfunctional myocardium with a functional replacement. However, a major …

Cardiovascular disease is one of the leading causes of mortality worldwide. Cardiac tissue
engineering strategies focusing on biomaterial scaffolds incorporating cells and growth …