Research involving nonhuman primates (NHPs) has played a vital role in many of the
medical and scientific advances of the past century. NHPs are used because of their …

Significance: The extracellular matrix (ECM) is a dynamic microenvironment that undergoes
continuous remodeling, particularly during injury and wound healing. Chronic liver injury of …

Reconstruction of heterogeneity through single cell transcriptional profiling has greatly
advanced our understanding of the spatial liver transcriptome in recent years. However …

Despite improvements in clinical management, pregnancies complicated by pre-existing
diabetes mellitus, gestational diabetes mellitus or obesity carry substantial risks for parent …

Maternal obesity (MO) is rising worldwide, affecting half of all gestations, constituting a
possible risk-factor for some pregnancy-associated liver diseases (PALD) and hepatic …

Key points Maternal obesity (MO) and exposure to a high‐fat, high‐simple‐carbohydrate diet
during pregnancy predisposes offspring to obesity, metabolic and cardiovascular disorders …

Intrauterine growth restriction (IUGR) is associated with reduced placental amino acid
transport (AAT). However, it remains to be established if changes in AAT contribute to …

The mammalian liver has a lobule structure with a portal triad consisting of the portal vein,
hepatic artery, and bile duct, which exhibits zonal gene expression, whereas those of …

Neurons controlling appetite are located in the hypothalamic arcuate (ARH) nuclei. Offspring
appetite regulation has been shown to be modified by dysregulation of ARH nuclear …

Adipose tissue metabolism is an essential factor in establishment of a successful lactation,
and we have a good understanding of changes in metabolic flux in relation to lactation …