If fully stretched out, a typical bacterial chromosome would be nearly 1 mm long,
approximately 1,000 times the length of a cell. Not only must cells massively compact their …

Bacteria come in a range of shapes, including round, rod-shaped, curved and spiral cells.
This morphological diversity implies that different mechanisms exist to guide proper cell …

Once described as mere “bags of enzymes,” bacterial cells are in fact highly organized, with
many macromolecules exhibiting nonuniform localization patterns. Yet the physical and …

As in eukaryotes, bacterial genomes are not randomly folded. Bacterial genetic information
is generally carried on a circular chromosome with a single origin of replication from which …

Visualization of living E. coli nucleoids, defined by HupA-mCherry, reveals a discrete,
dynamic helical ellipsoid. Three basic features emerge.(1) Nucleoid density coalesces into …

The bacterial chromosome must be compacted more than 1,000-fold to fit into the
compartment in which it resides. How it is condensed, organized and ultimately segregated …

Spatial organization is a hallmark of all living systems. Even bacteria, the smallest forms of
cellular life, display defined shapes and complex internal organization, showcasing a highly …

Despite recent progress in visualization experiments, the mechanism underlying
chromosome segregation in bacteria still remains elusive. Here we address a basic physical …

Phenotypic heterogeneity, defined as metastable variation in cellular parameters generated
by epigenetic mechanisms, is crucial for the persistence of bacterial populations under …

We have determined the three-dimensional (3D) architecture of the Caulobacter crescentus
genome by combining genome-wide chromatin interaction detection, live-cell imaging, and …