Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

The number and subunit composition of synaptic N-methyl-d-aspartate receptors (NMDARs)
are not static, but change in a cell-and synapse-specific manner during development and in …

The cellular processes that govern neuronal function are highly complex, with many basic
cell biological pathways uniquely adapted to perform the elaborate information processing …

Long-term potentiation and long-term depression are processes that have been widely
studied to understand the molecular basis of information storage in the brain. Glutamate …

Cytotoxic brain edema triggered by neuronal swelling is the chief cause of mortality
following brain trauma and cerebral infarct. Using fluorescence lifetime imaging to analyze …

Synapse formation and stabilization in the vertebrate central nervous system is a dynamic
process, requiring bi-directional communication between pre-and postsynaptic partners …

Regulation of AMPA receptor (AMPAR) trafficking is important for neural plasticity. Here we
examined the trafficking and synthesis of the GluR1 and GluR2 subunits using ReAsH-EDT2 …

The formation of synapses in the vertebrate central nervous system is a complex process
that occurs over a protracted period of development. Recent work has begun to unravel the …

Close structural and functional interactions of astrocytes with synapses play an important
role in brain function. The repertoire of ways in which astrocytes can regulate synaptic …

Cleavage of amyloid precursor protein (APP) by BACE-1 (β-site APP cleaving enzyme-1) is
the rate-limiting step in amyloid-β (Aβ) production and a neuropathologic hallmark of …