In contrast to other fat-soluble vitamins, dietary vitamin K is rapidly lost to the body resulting
in comparatively low tissue stores. Deficiency is kept at bay by the ubiquity of vitamin K in the …

The enzymes of the protein disulfide isomerase (PDI) family are thiol–disulfide
oxidoreductases of the endoplasmic reticulum (ER). They contain a CXXC active-site …

Suitable for advanced undergraduates and postgraduates, Understanding Bioinformatics
provides a definitive guide to this vibrant and evolving discipline. The book takes a …

Vitamin K‐dependent proteins require carboxylation of certain glutamates for their biological
functions. The enzymes involved in the vitamin K‐dependent carboxylation include: gamma …

Vitamin K epoxide reductase (VKOR) generates vitamin K hydroquinone to sustain γ-
carboxylation of many blood coagulation factors. Here, we report the 3.6 Å crystal structure …

Vitamin K is a collective term for lipid-like naphthoquinone derivatives synthesized only in
eubacteria and plants and functioning as electron carriers in energy transduction pathways …

The formation of structural disulfide bonds is essential for the function and stability of a great
number of proteins, particularly those that are secreted. There exists a variety of dedicated …

Following a request from the European Commission, the EFSA Panel on Dietetic Products,
Nutrition and Allergies (NDA) derives dietary reference values (DRV s) for vitamin K. In this …

In the 40‐year history of biopharmaceuticals, there have been a few cases where the final
products contained residual host cell protein (HCP) impurities at levels high enough to be of …

Background Coumarin derivatives have been in world-wide use for rodent pest control for
more than 50 years. Due to their retarded action as inhibitors of blood coagulation by …