Sox family transcription factors are well-established regulators of cell fate decisions during
development. Accumulating evidence documents that they play additional roles in adult …

Sox transcription factors play widespread roles during development; however, their versatile
funtions have a relatively simple basis: the binding of a Sox protein alone to DNA does not …

Maintain stemness, commit to a specific lineage, differentiate, proliferate, or die. These are
essential decisions that every cell is constantly challenged to make in multi-cellular …

Tissue and organ regeneration proceed in a coordinated manner to restore proper function
after trauma. Vertebrate skeletal muscle has a remarkable ability to regenerate after …

Adult skeletal muscle contains an abundant and highly accessible population of muscle
stem and progenitor cells called satellite cells. The primary function of satellite cells is to …

Dishevelled (DVL) proteins serve as crucial regulators that transduce canonical Wnt signals
to the GSK3β-destruction complex, resulting in the stabilization of β-catenin. Emerging …

Recent studies support the existence of a common progenitor for the cardiac and endothelial
cell lineages, but the underlying transcriptional networks responsible for specification of …

Myoglobin is a well-characterized, cytoplasmic hemoprotein that is expressed primarily in
cardiomyocytes and oxidative skeletal muscle fibers. However, recent studies also suggest …

The ability of adult peripheral sensory neurons to undergo functional and anatomical
recovery following nerve injury is due in part to successful activation of transcriptional …

Abstract BRCA1-associated protein-1 (BAP1) is a 729 residue, nuclear-localized
deubiquitinating enzyme (DUB) that displays tumor suppressor properties in the BAP1-null …